Evidence map›Paper›PMID 36403895›Full record

ArticleNeurobiology of disease2022

Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.

Shennan A Weiss, Laurent Sheybani, Nitish Seenarine, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Jerome Engel, Michael R Sperling, Yuval Nir, Richard J Staba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Shennan A WeissDept. of Neurology, State University of New York Downstate, Brooklyn, New York 11203, USA; Dept. of Physiology and Pharmacology, State University of New York Downstate, Brooklyn, New York 11203, USA; Dept. of Neurology, New York City Health + Hospitals/Kings County, Brooklyn, NY, USA. Electronic address: shennanweiss@gmail.com.
Laurent SheybaniEEG and Epilepsy Unit / Neurology, Department of Clinical Neuroscience, University Hospitals and Faculty of Medicine of University of Geneva, Geneva, Switzerland; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Nitish SeenarineDept. of Neurology, State University of New York Downstate, Brooklyn, New York 11203, USA; Dept. of Physiology and Pharmacology, State University of New York Downstate, Brooklyn, New York 11203, USA.
Itzhak FriedDept. of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Chengyuan WuDept. of Neuroradiology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Dept. of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ashwini SharanDept. of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Jerome EngelDept. of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Dept. of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Dept. of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Dept. of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Michael R SperlingDepts. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Yuval NirDepartment of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; The Sieratzki-Sagol Center for Sleep Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
Richard J StabaDept. of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Thomas Jefferson University · USUniversity of California, Los Angeles · USNew York City Health and Hospitals Corporation · USState University of New York · USTel Aviv University · ILUniversity College London · GB

Funding

IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR01NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME NONE ENGEL, Richard Staba · 1994 to 2026
$7.5M
In Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6M
Defining the Epileptogenic Network and Identifying Which Components Generate SeizuresR01NS106957 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Richard Staba · 2018 to 2026
$3.4M
Reducing or obviating the need for chronic intracranial electroencephalogram telemetry for epilepsy surgery patients by utilizing inter-ictal HFO rates: A study of diagnostic accuracyK23NS094633 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI WEISS, SHENNAN A · 2017 to 2018
$335k
NINDS NIH HHS K23 NS094633NINDS NIH HHS R01 NS033310NINDS NIH HHS R01 NS106957NINDS NIH HHS RF1 NS033310
6 · The paper itself

Abstract

Epileptiform spikes are used to localize epileptogenic brain tissue. The mechanisms that spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple (FR, 200-600 Hz) are biomarkers of epileptogenic brain, and we postulated that FR network interactions are involved in generating epileptiform spikes. Using macroelectrode stereo intracranial EEG (iEEG) recordings from a cohort of 46 patients we found that, in the seizure onset zone (SOZ), propagating FR were more often followed by an epileptiform spike, as compared with non-propagating FR (p < 0.05). Propagating FR had a distinct frequency and larger power (p < 1e-10) and were more strongly phase coupled to the peak of iEEG delta oscillation, which likely correspond with the DOWN states during non-REM sleep (p < 1e-8), than non-propagating FR. While FR propagation was rare, all FR occurred with the highest probability within +/- 400 msec of epileptiform spikes with superimposed high-frequency oscillations (p < 0.05). Thus, a sub-population of epileptiform spikes in the SOZ, are preceded by propagating FR that are coordinated by the DOWN state during non-REM sleep.

Indexed as

Brain WavesEpilepsies, PartialBrainElectrocorticographyElectroencephalographyHumansdown stateepileptiform dischargefast ripplefocal epilepsyhigh-frequency oscillationslow wave sleep

Identifiers

PMID36403895
PMCPMC12323987
OpenAlexW4309184626

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.