Evidence map›Paper›PMID 36403233›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Supramolecular Loading of DNA Hydrogels with Dye-Drug Conjugates for Real-Time Photoacoustic Monitoring of Chemotherapy.

Raina M Borum, Colman Moore, Yash Mantri, Ming Xu, Jesse V Jokerst

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raina M BorumDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093, United States.ORCID https://orcid.org/0000-0003-4265-3109
Colman MooreDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093, United States.ORCID https://orcid.org/0000-0002-1809-5955
Yash MantriDepartment of BioEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093, United States.ORCID https://orcid.org/0000-0002-6689-2158
Ming XuDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093, United States.
Jesse V JokerstDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093, United States.ORCID https://orcid.org/0000-0003-2829-6408

Funding

Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
Imaging SARS-CoV-2 proteases for spatio-temporal insight into Covid-19R21AI157957 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2020
$434k
NCI NIH HHS T32 CA153915NHLBI NIH HHS DP2 HL137187NIAID NIH HHS R21 AI157957NIH HHS S10 OD021821ODCDC CDC HHS S10 OD021821
6 · The paper itself

Abstract

A longstanding problem with conventional cancer therapy is the nonspecific distribution of chemotherapeutics. Monitoring drug release in vivo via noninvasive bioimaging can thus have value, but it is difficult to distinguish loaded from released drug in live tissue. Here, this work describes an injectable supramolecular hydrogel that allows slow and trackable release of doxorubicin (Dox) via photoacoustic (PA) tomography. Dox is covalently linked with photoacoustic methylene blue (MB) to monitor Dox before, during, and after release from the hydrogel carrier. The conjugate (MB-Dox) possesses an IC50 of 161.4 × 10

Indexed as

bioimagingdrug deliverydrug monitoringhydrogelimage-guided therapyin vivo molecular imagingphotoacoustic imaging

Identifiers

PMID36403233
PMCPMC9811488

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.