Evidence map›Paper›PMID 36403045›Full record

ArticleMalaria journal2022

Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area.

Samuel Tassi Yunga, Chathura Siriwardhana, Genevieve G Fouda, Naveen Bobbili, Grace Sama, John J Chen, Rose F G Leke, Diane Wallace Taylor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Dynamics of IgG antibody response againstFrontiers in immunology · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Samuel Tassi YungaDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Bioscience Building Suite 320, Honolulu, HI, 96813, USA. tassiyun@ohsu.edu.
Chathura SiriwardhanaDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, MEB411, Honolulu, HI, 96813, USA.
Genevieve G FoudaDepartment of Pediatrics, Joan & Sanford I. Weill Medical College of Cornell University, New York, NY, USA.
Naveen BobbiliDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Bioscience Building Suite 320, Honolulu, HI, 96813, USA.
Grace SamaThe Biotechnology Center, University of Yaoundé 1, Messa, BP 3851, Yaoundé, Cameroon.
John J ChenDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, MEB411, Honolulu, HI, 96813, USA.
Rose F G LekeThe Biotechnology Center, University of Yaoundé 1, Messa, BP 3851, Yaoundé, Cameroon.
Diane Wallace TaylorDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Bioscience Building Suite 320, Honolulu, HI, 96813, USA. dwtaylor@hawaii.edu.
University of Hawaiʻi at Mānoa · USUniversité de Yaoundé I · CMCornell University · US

Funding

The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Lee Ellen Buenconsejo-Lum, Jerris Robert Hedges · 2017 to 2026
$59.5M
Malarial Immunity in Pregnant Cameroonian WomenR01AI071160 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI TAYLOR, DIANE WALLACE · 2007 to 2011
$3.0M
TH2 BIAS EFFECT ON MALARIAL IMMUNITY IN CAMEROONU01AI043888 · NIAID · GEORGETOWN UNIVERSITY · PI TAYLOR, DIANE WALLACE · 1998 to 2002
$2.7M
Training of Cameroonian Scientists in Research on MalariaD43TW009074 · FIC · UNIVERSITY OF HAWAII AT MANOA · PI NERURKAR, VIVEK RAMCHANDRA · 2011 to 2015
$978k
TRAINING OF CAMEROONIAN SCIENTISTSD43TW001264 · FIC · GEORGETOWN UNIVERSITY · PI TAYLOR, DIANE WALLACE · 1999 to 2003
$783k
Defining Immunity to Placental Malaria using a Multi-assay Predictive ModelR21AI105286 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI CHEN, JOHN J, TAYLOR, DIANE WALLACE · 2014 to 2015
$418k
FIC NIH HHS D43 TW001264FIC NIH HHS D43TW001264; D43TW009074FIC NIH HHS D43 TW009074NIAID, NIH UO1AI43888; RO1AI071160; R21AI105286NIAID NIH HHS R01 AI071160NIAID NIH HHS R21 AI105286NIAID NIH HHS U01 AI043888NIMHD, NIH U54MD007601NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

backgroundThe primary antibody (Ab) response to Plasmodium falciparum is a critical step in developing immunity to malaria. Information on the initial Ab responses of babies in malaria-endemic areas is incomplete, in part, because babies receive maternal IgG via transplacental-transfer and usually become infected before maternal IgG wanes. The study aimed to identify the primary IgM and IgG Ab responses to malarial antigens in Cameroonian babies.

methodsInfants (n = 70) living in a high malaria transmission area were followed from birth throughout the first year of life (mean 341 ± 42 days, an average of 8.5 time points per infant). Malaria infection was assessed by microscopy and PCR, and IgM and IgG antibodies (Abs) were measured using a multiplex immunoassay to AMA1, EBA-175, MSP1-42, MSP2, MSP3, RESA, LSA1, and CSP.

resultsThe half-life of maternal IgG varied among the antigens, ranging from 0.7 to 2.5 months. The first infection of 41% of the babies was sub-microscopic and only 11 to 44% of the babies produced IgM to the above antigens; however, when the first infection was detected by microscopy, 59-82% of the infants made IgM Abs to the antigens. Infants were able to produce IgM even when maternal IgG was present, suggesting maternal Abs did not suppress the baby's initial Ab response. Using longitudinal regression models that incorporated time-varying covariates, infants were found to produce IgG Ab to only AMA-1 when the first infection was sub-microscopic, but they produced IgG Abs to MSP1-42 (3D7, FVO), AMA1 (3D7, FVO) MSP2-FC27, MSP3, RESA, and LSA1, but not MSP 2-3D7, EBA-175, and CSP during their first slide-positive infection. Notably, the primary and secondary IgG responses were short-lived with little evidence of boosting.

conclusionsThe primary Ab response of babies who had maternal IgG was similar to that reported for primary infections in malaria-naïve adults.

Indexed as

MalariaMalaria, FalciparumAdultAntibodies, ProtozoanAntibody FormationAntigens, ProtozoanHumansImmunoglobulin GImmunoglobulin MInfantMerozoite Surface Protein 1Plasmodium falciparumAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin GImmunoglobulin MMerozoite Surface Protein 1BabiesFirst antibody responseIgGIgMMalariaPlasmodium falciparum

Identifiers

PMID36403045
PMCPMC9675181
OpenAlexW4309562023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.