Evidence map›Paper›PMID 36402981›Full record

ArticleBMC ophthalmology2022

The possible pathogenesis of macular caldera in patients with North Carolina macular dystrophy.

Zhe Zhu, He Zou, Chuanyu Li, Bainan Tong, Chenchen Zhang, Jun Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhe ZhuMedical Retina, Eye Center of the Second Hospital of Jilin University, Room 304, 3Rd Floor, Out Patient Building, No.218, Ziqiang Street, Nanguan District, Changchun City, Jilin Province, China.
He ZouEye Center of the Second Hospital of Jilin University, Changchun City, Jilin Province, China.
Chuanyu LiMedical Retina, Eye Center of the Second Hospital of Jilin University, Room 304, 3Rd Floor, Out Patient Building, No.218, Ziqiang Street, Nanguan District, Changchun City, Jilin Province, China.
Bainan TongMedical Retina, Eye Center of the Second Hospital of Jilin University, Room 304, 3Rd Floor, Out Patient Building, No.218, Ziqiang Street, Nanguan District, Changchun City, Jilin Province, China.
Chenchen ZhangEye Center of the Second Hospital of Jilin University, Changchun City, Jilin Province, China.
Jun XiaoMedical Retina, Eye Center of the Second Hospital of Jilin University, Room 304, 3Rd Floor, Out Patient Building, No.218, Ziqiang Street, Nanguan District, Changchun City, Jilin Province, China. xiaoj@jlu.edu.cn.ORCID http://orcid.org/0000-0002-9580-4049
Second Affiliated Hospital of Jilin University · CN

Funding

Department of Finance of Jilin Province 2020SCZT008
6 · The paper itself

Abstract

backgroundThis study provides a detailed description of a Chinese family with North Carolina macular dystrophy (NCMD) and explores its possible pathogenesis.

methodsFive individuals from a three-generation family underwent general ophthalmic examination, multi-imaging examinations and visual electrophysiology examinations when possible. Genetic characterization was carried out by target region sequencing and high-throughput sequencing in affected patients.

resultsDespite severe fundus changes, patients had relatively good visual acuity. Genetic analysis showed that affected patients had PRDM13 gene duplication and heterozygous mutations of the ABCA4 gene. Optical coherence tomography (OCT) showed an abnormal retinal pigment epithelium (RPE) layer in patients with grade 2 lesions, while the neurosensory retina was relatively normal. In grade 3 patients, RPE and choroid atrophy were greater than that of the neurosensory retina, showing concentric atrophy.

conclusionsRPE and choroidal atrophy were found to play an important role in the development of macular caldera.

Indexed as

Corneal Dystrophies, HereditaryATP-Binding Cassette TransportersAtrophyHumansPedigreeTomography, Optical CoherenceABCA4 protein, humanATP-Binding Cassette TransportersChinese familyNorth Carolina macular dystrophyPathogenesisPRDM13

Identifiers

PMID36402981
PMCPMC9675142
OpenAlexW4309561673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.