Observational studyThe journal of headache and pain2022
Microvascular decompression in trigeminal neuralgia - a prospective study of 115 patients.
Observational study in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04445766 (Efficacy and Complications of Microvascular Decompression - a Prospective Systematic Study of 115 Trigeminal Neuralgia Patients), which is not on this map. Cited by 41 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Complications of Microvascular Decompression - a Prospective Systematic Study of 115 Trigeminal Neuralgia Patients
Who cites it
41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- The efficacy of surgical interventions for trigeminal neuralgia in multiple sclerosis: A systematic review.Neurosurgical review · 2026Pooled it
- Beyond the Pain: Rethinking Chronic Pain Management Through Integrated Therapeutic Approaches-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Outcomes of trigeminal nerve microsurgical internal neurolysis for trigeminal neuralgia without neurovascular conflict: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Efficacy and safety of microvascular decompression with or without partial sensory rhizotomy: a comprehensive meta-analysis and systematic review in treating trigeminal neuralgia.Neurosurgical review · 2024Pooled it
- Effectiveness of gamma knife radiosurgery in the management of trigeminal neuralgia associated with multiple sclerosis: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Comparison of the efficacy in improving trigeminal neuralgia in petroclival meningioma between microsurgery and radiosurgery: a meta-analysis.Neurosurgical review · 2023Pooled it
- Multimodal MRI fusion and three-dimensional reconstruction for preoperative assessment of neurovascular compression in trigeminal neuralgia: A retrospective study.Neurosurgical review · 2026Article
- Exploratory development of prediction models for pharmacotherapy outcomes in trigeminal neuralgia: a combined analysis based on multi-source data.The journal of headache and pain · 2026Article
- Neurovascular Compression Syndromes of Cranial Nerves: A Multidisciplinary Guide to Management.Brain sciences · 2026Review
- Outcomes of repeat microvascular decompression versus percutaneous balloon compression for recurrent trigeminal neuralgia.Neurosurgical review · 2026Observational
- Pivotal Factors for Minimizing the Risks of Therapeutic Failure in Trigeminal Neuralgia and Hemifacial Spasm.Current pain and headache reports · 2026Review
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- Identification and validation of candidate biomarkers associated with mitochondria and 18 types of programmed cell death in trigeminal neuralgia: insights from transcriptome sequencing.Frontiers in molecular neuroscience · 2026Article
- Article
- Five-year prospective outcomes of medical management and microvascular decompression in trigeminal neuralgia.Journal of neurology · 2025Observational
- A comparison of long-term outcomes between interposition with teflon and autologous muscle in microvascular decompression for trigeminal neuralgia.Neurosurgical review · 2025Article
- Efficacy of microvascular decompression versus percutaneous balloon compression in trigeminal neuralgia: a propensity-matched retrospective analysis.Neurosurgical review · 2025Article
- Efficacy of microvascular decompression in the treatment of trigeminal neuralgia: a retrospective Single-Center study of 28 cases.Neurosurgical review · 2025Article
- Glymphatic and neurofluidic dysfunction in classical trigeminal neuralgia: a multimodal MRI study of brain-CSF functional and structural dynamics.BMC medical imaging · 2025Article
- Long-Term Effectiveness of Early Versus Late Microvascular Decompression for Trigeminal Neuralgia Secondary to Arterial Compression.European journal of neurology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrigeminal neuralgia is a severe facial pain disorder. Microvascular decompression is first choice surgical treatment of patients with classical TN. There exist few prospective studies with an independent evaluation of efficacy and complications after MVD.
objectivesWe aimed to assess outcome and complications after microvascular decompression from our center.
methodsWe prospectively recorded clinical characteristics, outcome, and complications from consecutive patients with either classical or idiopathic (only patients with a neurovascular contact) trigeminal neuralgia undergoing microvascular decompression. Neurovascular contact was evaluated by 3.0 Tesla MRI. Patients were assessed before and 3, 6, 12, and 24 months after surgery by independent assessors.
resultsOf 115 included patients, 86% had a clinically significant outcome (i.e., BNI I - BNI IIIb). There was a significant association between an excellent surgical outcome and the male sex (OR 4.9 (CI 1.9-12.8), p = 0.001) and neurovascular contact with morphological changes (OR 2.5 (CI 1.1-6.0), p = 0.036). Significantly more women (12/62 = 19%) than men (2/53 = 4%) had a failed outcome, p = 0.019. The most frequent major complications were permanent hearing impairment (10%), permanent severe hypoesthesia (7%), permanent ataxia (7%), and stroke (6%). Most patients (94%) recommend surgery to others.
conclusionMicrovascular decompression is an effective treatment for classical and idiopathic (only patients with a neurovascular contact) trigeminal neuralgia with a high chance of a long-lasting effect. The chance of an excellent outcome was highest in men and in patients with classical trigeminal neuralgia. Complications are relatively frequent warranting thorough patient evaluation and information preoperatively.
trial registrationClinical. TRIALS: gov registration no. NCT04445766 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.