Evidence map›Paper›PMID 36402869›Full record

ArticleCerebellum (London, England)2023

Neuronal Nitric Oxide Synthase Critically Regulates the Endocannabinoid Pathway in the Murine Cerebellum During Development.

Vasiliki Tellios, Matthew J E Maksoud, Ravneet Nagra, Gurneet Jassal, Wei-Yang Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vasiliki TelliosGraduate Program of Neuroscience, The University of Western Ontario, London, N6A 5B7, Canada.ORCID http://orcid.org/0000-0002-2976-9951
Matthew J E MaksoudGraduate Program of Neuroscience, The University of Western Ontario, London, N6A 5B7, Canada.
Ravneet NagraRobarts Research Institute, London, N6A 5B7, Canada.
Gurneet JassalDepartment of Physiology and Pharmacology, The University of Western Ontario, London, N6A 5B7, Canada.
Wei-Yang LuGraduate Program of Neuroscience, The University of Western Ontario, London, N6A 5B7, Canada. wlu53@uwo.ca.
Western University · CARobarts Clinical Trials · CA

Funding

CIHR MOP-133504
6 · The paper itself

Abstract

The cerebellum is a major site of endocannabinoid (eCB) production and signaling. The predominant eCB within the cerebellum, 2-arachidonoylglycerol (2-AG), is produced by a metabotropic glutamate receptor type 1 (mGluR1)-initiated signaling cascade within Purkinje neurons (PNs). 2-AG retrogradely stimulates cannabinoid 1 receptors (CB1Rs) located on presynaptic terminals. The activated CB1R decreases neurotransmitter release and leads to the production of nitric oxide (NO), a gaseous molecule. Recently, our group discovered that during development in mice lacking neuronal nitric oxide synthase (nNOS

Indexed as

CerebellumEndocannabinoidsAnimalsMiceNitric OxideNitric Oxide Synthase Type IPurkinje CellsSynaptic TransmissionEndocannabinoidsNitric OxideNitric Oxide Synthase Type ICannabinoid receptor-1CerebellumEndocannabinoidsMetaNeuronal nitric oxide synthase

Identifiers

PMID36402869
OpenAlexW4309405355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.