Evidence map›Paper›PMID 36402838›Full record

ArticleScientific data2022

Unifying the identification of biomedical entities with the Bioregistry.

Charles Tapley Hoyt, Meghan Balk, Tiffany J Callahan, Daniel Domingo-Fernández, Melissa A Haendel, Harshad B Hegde, Daniel S Himmelstein, Klas Karis, John Kunze, Tiago Lubiana and 9 more

Abstract read
In one paragraph

Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. AI semantics for biomedical data integration.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Usage and impact of global biodata resources.Bioinformatics advances · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Charles Tapley HoytLaboratory of Systems Pharmacology, Harvard Medical School, Boston, USA.
Meghan BalkUniversity of Arizona, Tucson, USA.ORCID 0000-0003-2699-3066
Tiffany J CallahanUniversity of Colorado Anschutz Medical Campus, Aurora, USA.
Daniel Domingo-FernándezDepartment of Bioinformatics, Fraunhofer SCAI, Sankt Augustin, Germany.
Melissa A HaendelUniversity of Colorado Anschutz Medical Campus, Aurora, USA.
Harshad B HegdeLawrence Berkeley National Laboratory, Berkeley, USA.
Daniel S HimmelsteinRelated Sciences, Denver, USA.ORCID 0000-0002-3012-7446
Klas KarisLaboratory of Systems Pharmacology, Harvard Medical School, Boston, USA.ORCID 0000-0003-1699-7776
John KunzeCalifornia Digital Library, University of California, Berkeley, USA.
Tiago LubianaSchool of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Nicolas MatentzogluSemanticly, London, UK.
Julie McMurryUniversity of Colorado Anschutz Medical Campus, Aurora, USA.
Sierra MoxonLawrence Berkeley National Laboratory, Berkeley, USA.
Christopher J MungallLawrence Berkeley National Laboratory, Berkeley, USA.
Adriano RutzSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-0443-9902
Deepak R UnniLawrence Berkeley National Laboratory, Berkeley, USA.
Egon WillighagenDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, Netherlands.ORCID 0000-0001-7542-0286
Donald WinstonPolyneme LLC, New York, USA.
Benjamin M GyoriLaboratory of Systems Pharmacology, Harvard Medical School, Boston, USA. benjamin_gyori@hms.harvard.edu.ORCID 0000-0001-9439-5346

Funding

The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
Improvements to the LinkML framework to support the Phenomics First open science resourceRM1HG010860 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2020 to 2024
$10.3M
NHGRI NIH HHS RM1 HG010860NIH HHS R24 OD011883
6 · The paper itself

Abstract

The standardized identification of biomedical entities is a cornerstone of interoperability, reuse, and data integration in the life sciences. Several registries have been developed to catalog resources maintaining identifiers for biomedical entities such as small molecules, proteins, cell lines, and clinical trials. However, existing registries have struggled to provide sufficient coverage and metadata standards that meet the evolving needs of modern life sciences researchers. Here, we introduce the Bioregistry, an integrative, open, community-driven metaregistry that synthesizes and substantially expands upon 23 existing registries. The Bioregistry addresses the need for a sustainable registry by leveraging public infrastructure and automation, and employing a progressive governance model centered around open code and open data to foster community contribution. The Bioregistry can be used to support the standardized annotation of data, models, ontologies, and scientific literature, thereby promoting their interoperability and reuse. The Bioregistry can be accessed through https://bioregistry.io and its source code and data are available under the MIT and CC0 Licenses at https://github.com/biopragmatics/bioregistry .

Identifiers

PMID36402838
PMCPMC9675740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.