ArticleSchizophrenia bulletin2023
Controllability of Functional Brain Networks and Its Clinical Significance in First-Episode Schizophrenia.
Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis.Molecular psychiatry · 2025Pooled it
- Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit/hyperactivity disorder.BMC medicine · 2024Pooled it
- Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditory hallucinations.Translational psychiatry · 2025Trial
- Intranasal insulin enhances resting-state functional connectivity in Type 2 Diabetes.PloS one · 2025Trial
- Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks.Dialogues in clinical neuroscience · 2026Review
- Schizophrenia: Converging Neurobiological Mechanisms and Emerging Therapeutic Strategies.Biomolecules · 2026Review
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
- Age of Onset, Brain Controllability, and Working Memory Performance in First-Episode Schizophrenia.Schizophrenia bulletin · 2026Article
- Unraveling the Individualized Shared and Distinct Dynamic Functional Connectivity in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome.CNS neuroscience & therapeutics · 2026Article
- Reduced emotion-generated frontolimbic functional connectivity in psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder.European child & adolescent psychiatry · 2026Article
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.CNS neuroscience & therapeutics · 2026Article
- Dorsal anterior cingulate cortex-targeted transcranial temporal interference stimulation for negative symptoms and cognitive impairment in schizophrenia: a participant- and assessor-blinded, sham-controlled randomized controlled trial protocol.Frontiers in psychiatry · 2026Article
- Brain network controllability in genetic risk, childhood abuse, and adult anxiety.European journal of psychotraumatology · 2025Article
- Heterogeneity of brain functional connectivity, transcriptome, and neurotransmitter profiles in major depressive disorder.Psychological medicine · 2025Article
- Multimodal biological profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2025Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and hypothesisDisrupted control of brain state transitions may contribute to the diverse dysfunctions of cognition, emotion, and behavior that are fundamental to schizophrenia. Control theory provides the rationale for evaluating brain state transitions from a controllability perspective, which may help reveal the brain mechanism for clinical features such as cognitive control deficits associated with schizophrenia. We hypothesized that brain controllability would be altered in patients with schizophrenia, and that controllability of brain networks would be related to clinical symptomatology. STUDY
designControllability measurements of functional brain networks, including average controllability and modal controllability, were calculated and compared between 125 first-episode never-treated patients with schizophrenia and 133 healthy controls (HCs). Associations between controllability metrics and clinical symptoms were evaluated using sparse canonical correlation analysis. STUDY
resultsCompared to HCs, patients showed significantly increased average controllability (PFDR = .023) and decreased modal controllability (PFDR = .023) in dorsal anterior cingulate cortex (dACC). General psychopathology symptoms and positive symptoms were positively correlated with average controllability in regions of default mode network and negatively associated with average controllability in regions of sensorimotor, dorsal attention, and frontoparietal networks.
conclusionsOur findings suggest that altered controllability of functional activity in dACC may play a critical role in the pathophysiology of schizophrenia, consistent with the importance of this region in cognitive and brain state control operations. The demonstration of associations of functional controllability with psychosis symptoms suggests that the identified alterations in average controllability of brain function may contribute to the severity of acute psychotic illness in schizophrenia.
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