Evidence map›Paper›PMID 36402006›Full record

ReviewCurrent opinion in chemical biology2023

Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains.

Andrew D Gnann, Kenneth Marincin, Dominique P Frueh, Daniel P Dowling

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew D GnannDepartment of Chemistry, University of Massachusetts Boston, Boston, MA, 02125, USA.
Kenneth MarincinDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Dominique P FruehDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Daniel P DowlingDepartment of Chemistry, University of Massachusetts Boston, Boston, MA, 02125, USA. Electronic address: Daniel.Dowling@umb.edu.

Funding

NMR studies of heterocyclization and epimerization in yersiniabactin synthesisR01GM104257 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FRUEH, DOMINIQUE PASCAL · 2013 to 2023
$3.0M
Molecular Determinants of Natural Product HeterocyclizationR15GM123425 · NIGMS · UNIVERSITY OF MASSACHUSETTS BOSTON · PI DOWLING, DANIEL P. · 2017 to 2017
$445k
NIGMS NIH HHS R01 GM104257NIGMS NIH HHS R15 GM123425
6 · The paper itself

Abstract

Ox-/thiazoline groups in nonribosomal peptides are formed by a variant of peptide-forming condensation domains called heterocyclization (Cy) domains and appear in a range of pharmaceutically important natural products and virulence factors. Recent cryo-EM, crystallographic, and NMR studies of Cy domains make it opportune to revisit outstanding questions regarding their molecular mechanisms. This review covers structural and dynamical findings about Cy domains that will inform future bioengineering efforts and our understanding of natural product synthesis.

Indexed as

PeptidesPeptide SynthasesCyclizationProtein Domainsnon-ribosomal peptide synthasePeptidesPeptide SynthasesAllosteryBioengineeringCyclodehydrationHeterocyclePantetheineProtein–protein interactions

Identifiers

PMID36402006
PMCPMC12173477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.