Evidence map›Paper›PMID 36401274›Full record

ArticleTrials2022

Effect of intraoperative goal-directed fluid therapy on the postoperative brain edema in patients undergoing high-grade glioma resections: a study protocol of randomized control trial.

Xiaoyuan Liu, Xingyue Zhang, Yifang Fan, Shu Li, Yuming Peng

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03323580 (Effects of Intraoperative Goal-directed Fluid Therapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03323580 nacompletednot on this map

Effects of Intraoperative Goal-directed Fluid Therapy (GDFT) on the Postoperative Brain Edema in Neurosurgical Patients With Malignant Supratentorial Gliomas

TypeinterventionalSponsorBeijing Tiantan HospitalRan2018 to 2022Enrolled480ConditionsFluid Therapy, Brain Edema, Brain TumorArmsGDFT, traditional fluid therapy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaoyuan Liu *Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No.119, Nansihuan Xilu, Fengtai District, Beijing, 100070, People's Republic of China.
Xingyue Zhang *Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No.119, Nansihuan Xilu, Fengtai District, Beijing, 100070, People's Republic of China.
Yifang FanDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No.119, Nansihuan Xilu, Fengtai District, Beijing, 100070, People's Republic of China.
Shu LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No.119, Nansihuan Xilu, Fengtai District, Beijing, 100070, People's Republic of China.
Yuming PengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No.119, Nansihuan Xilu, Fengtai District, Beijing, 100070, People's Republic of China. pengyuming@bjtth.org.ORCID http://orcid.org/0000-0002-2630-2467
Capital Medical University · CN

Funding

Beijing Municipal Administration of Hospitals Incubating Program PX2019018
6 · The paper itself

Abstract

introductionBrain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on postoperative brain edema and the prognosis remain unclear. METHODS AND ANALYSIS: This is a prospective, randomized, double-blinded, parallel-controlled trial aiming to observe whether stroke volume variation (SVV)-based GDFT could improve the postoperative brain edema in patients undergoing supratentorial high-grade gliomas compared with traditional fluid therapy. The patient will be given 3 ml/kg hydroxyethyl starch solution when the SVV is greater than 15% continuously for more than 5 min intraoperatively. The primary outcome will be postoperative cerebral edema volume on brain CT within 24 h. ETHICS AND DISSEMINATION: This trial has been registered at ClinicalTrials.gov (NCT03323580) and approved by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-067-02). The findings will be disseminated in peer-reviewed journals and presented at national or international conferences relevant to the subject fields.

trial registrationClinicalTrials.gov NCT03323580 (First posted: October 27, 2017; Last update posted: February 11, 2022).

Indexed as

Brain EdemaFluid TherapyGliomaGoalsHumansProspective StudiesRandomized Controlled Trials as Topic

Identifiers

PMID36401274
PMCPMC9675213
OpenAlexW4309467320

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.