Evidence map›Paper›PMID 36401251›Full record

ArticleBMC endocrine disorders2022

Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study.

Joel Nuotio, Teemu Niiranen, Tomi T Laitinen, Jessica Miller, Matthew A Sabin, Aki S Havulinna, Jorma S A Viikari, Tapani Rönnemaa, Nina Hutri-Kähönen, Tomi P Laitinen and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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  8. Is There Evidence to Support Probiotic Use for Healthy People?Advances in nutrition (Bethesda, Md.) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Joel NuotioResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland. joel.nuotio@utu.fi.
Teemu NiiranenFinnish Institute for Health and Welfare, Helsinki, Finland.
Tomi T LaitinenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland.
Jessica MillerMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
Matthew A SabinMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
Aki S HavulinnaFinnish Institute for Health and Welfare, Helsinki, Finland.
Jorma S A ViikariDepartment of Internal Medicine, University of Turku, Turku, Finland.
Tapani RönnemaaDepartment of Internal Medicine, University of Turku, Turku, Finland.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University and Tampere University Hospital, Tampere, Finland.
Tomi P LaitinenDepartment of Clinical Physiology and Nuclear Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Päivi TossavainenDepartment of Pediatrics, Oulu University Hospital and University of Oulu, Oulu, Finland.
Veikko SalomaaFinnish Institute for Health and Welfare, Helsinki, Finland.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland.
David P BurgnerMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
Markus JuonalaMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
University of Turku · FIMurdoch Children's Research Institute · AUFinnish Institute for Health and Welfare · FIOulu University Hospital · FITampere University Hospital · FITurku University Hospital · FIUniversity of Eastern Finland · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate whether exposure to systemic antibiotics influences the risk of developing type 2 diabetes and overweight/obesity.

methodsThe study sample comprised 2209 (110 with incident diabetes) participants from the population-based Cardiovascular Risk in Young Finns Study (YFS) aged 24-39 years in 2001. The exposure was national linked register data on purchased antibiotic courses between 1993 and 2001. Clinical examinations including BMI were conducted in 2001, 2007 and 2011. Participants with prevalent diabetes in 2001 were excluded. Data on type 2 diabetes was also obtained from two national registers until 2017. Data from four population-based National FINRISK studies were used for replication (N = 24,674, 1866 with incident diabetes).

resultsPrior antibiotic exposure (> 5 versus 0-1 antibiotic courses) was associated with subsequent type 2 diabetes in both YFS (OR 2.29; 95%CI 1.33-3.96) and FINRISK (HR 1.73; 95%CI 1.51-1.99). An increased risk for type 2 diabetes was observed in YFS (OR 1.043; 95%CI 1.013-1.074) and FINRISK (HR 1.022; 95%CI 1.016-1.029) per course. Exposure to antibiotics increased the risk of overweight/obesity (BMI > 25 kg/m

conclusionOur results show that exposure to antibiotics was associated with increased risk for future type 2 diabetes and overweight/obesity and support judicious antibiotic prescribing.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Anti-Bacterial AgentsFinlandHeart Disease Risk FactorsHumansObesityOverweightRisk FactorsAnti-Bacterial AgentsAntibioticsObesityType 2 diabetes

Identifiers

PMID36401251
PMCPMC9673285
OpenAlexW4309467645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.