ReviewPediatric rheumatology online journal2022
Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis: results from the international Pharmachild registry.
Review in Pediatric rheumatology online journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Clinical Profile and Diagnostic Spectrum of Autoimmune Comorbidities in Juvenile Idiopathic Arthritis: A Descriptive Single-Centre Observational Study.Diagnostics (Basel, Switzerland) · 2026Article
- Autoimmune/immune rheumatic diseases in family members of children with enthesitis related arthritis and other categories of juvenile idiopathic arthritis: a study from India.Clinical rheumatology · 2025Article
- Endocrine dysfunctions as complications and comorbidities of juvenile idiopathic arthritis.Reumatologia · 2025Review
- Article
- Conundrum for Psoriasis and Thyroid Involvement.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 5 countries.
Funding
Abstract
backgroundLittle is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in parents of children with juvenile idiopathic arthritis (JIA).
methodsPrevalence rates of ADs and 95% Poisson confidence intervals were calculated for parents of JIA patients from the international Pharmachild registry and compared with general population prevalence rates as reported in the literature. Demographic, clinical and laboratory features were compared between JIA patients with and without a family history of AD using χ
resultsEight thousand six hundred seventy three patients were included and the most common familial ADs were psoriasis, autoimmune thyroid disease, rheumatoid arthritis and ankylosing spondylitis. The prevalence of several ADs was higher in parents of the included JIA patients than in the general population. Clinical Juvenile Arthritis Disease Activity Scores at study entry and last follow-up were not significantly different between patients with (n = 1231) and without a family history of AD (n = 7442). Factors associated with familial AD were older age at JIA onset (P < 0.01), Scandinavian residence (P < 0.01), enthesitis-related arthritis, psoriatic arthritis and undifferentiated arthritis (P < 0.01), ANA positivity (P = 0.03) and HLA-B27 positivity (P < 0.01).
conclusionsFamilial AD proves to be a risk factor for JIA development and certain diseases should therefore not be overlooked during family health history at the diagnosis stage. A family history of AD is associated with the JIA category but does not influence the severity or disease course.
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