ArticleThe journal of headache and pain2022
Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients.
Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Morpho-Histo-Cytological Evaluation of Oral Tissues in Burning Mouth Syndrome: A Systematic Review.Journal of oral rehabilitation · 2025Pooled it
- Mechanisms Underlying Burning Mouth Syndrome and Occlusal Dysesthesia: Shared and Distinct Pathways of Oral Sensory Dysregulation.Journal of oral rehabilitation · 2026Review
- Use of soft intraoral appliance for refractory burning mouth syndrome: an exploratory case series.BMC oral health · 2026Article
- Burning mouth syndrome: updates on pathogenesis and diagnostic algorithms.Journal of oral & facial pain and headache · 2025Review
- Potential Target Receptors for the Pharmacotherapy of Burning Mouth Syndrome.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Xerostomia correlates with pain sensitivity in burning mouth syndrome patients.Scientific reports · 2025Article
- Time-course of pain and salivary opiorphin release in response to oral capsaicin differ in burning mouth syndrome patients, temporomandibular disorders patients and control subjects.Clinical oral investigations · 2024Observational
- The enigma of burning mouth syndrome: Insights into dual pain mechanisms.Journal of dental sciences · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeficient endogenous pain modulation has been implicated in the development and exacerbation of chronic orofacial pain. To date, relatively little is known regarding the function of the endogenous pain modulation in patients with burning mouth syndrome (BMS). This case-control study investigated endogenous pain modulation in women with BMS.
methodsConditioned pain modulation (CPM) was assessed upon temporal summation (TSP) of thermal pain. Forty female subjects, 20 BMS patients and 20 age-matched control subjects, were included in a 2 session-protocol. Mechanical and thermal pain thresholds were measured on the forearm and hand. TSP was obtained using repetitive laser-evoked thermal stimuli applied on the non-dominant hand, at an intensity yielding to moderate pain. During TSP, CPM was produced by immersing the contralateral foot in a water bath at painful cold (8 °C) temperature. In control conditions, the foot was immersed in a water bath at not painful (30 °C) temperature.
resultsBMS was not associated with any impairment in thermal as well as mechanical extracephalic pain thresholds. TSP and CPM efficacy were similar in BMS patients and control subjects. However, BMS patients exhibited enhanced extracephalic heat hyperalgesia.
conclusionThis study reveals that there is no impairment of endogenous pain inhibition mechanisms in BMS patients, but rather an increase in pain facilitation.
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