Evidence map›Paper›PMID 36401093›Full record

ReviewCell and tissue research2023

Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system.

Tatjana Abaffy, Hsiu-Yi Lu, Hiroaki Matsunami

Open access · hybridAbstract readReview
In one paragraph

Review in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tatjana AbaffyMolecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC, 27710, USA. tatjana.abaffy@duke.edu.ORCID http://orcid.org/0000-0002-2887-1858
Hsiu-Yi LuMolecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC, 27710, USA.
Hiroaki MatsunamiMolecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC, 27710, USA.
Duke Medical Center · USDuke University · US

Funding

Biogenesis of olfactory G protein-coupled receptorsR01DC016224 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2017 to 2021
$2.2M
NIDCD NIH HHS DC016224NIDCD NIH HHS R01 DC016224
6 · The paper itself

Abstract

Sex steroid hormones influence olfactory-mediated social behaviors, and it is generally hypothesized that these effects result from circulating hormones and/or neurosteroids synthesized in the brain. However, it is unclear whether sex steroid hormones are synthesized in the olfactory epithelium or the olfactory bulb, and if they can modulate the activity of the olfactory sensory neurons. Here, we review important discoveries related to the metabolism of sex steroids in the mouse olfactory epithelium and olfactory bulb, along with potential areas of future research. We summarize current knowledge regarding the expression, neuroanatomical distribution, and biological activity of the steroidogenic enzymes, sex steroid receptors, and proteins that are important to the metabolism of these hormones and reflect on their potential to influence early olfactory processing. We also review evidence related to the effects of sex steroid hormones on the development and activity of olfactory sensory neurons. By better understanding how these hormones are metabolized and how they act both at the periphery and olfactory bulb level, we can better appreciate the complexity of the olfactory system and discover potential similarities and differences in early olfactory processing between sexes.

Indexed as

Gonadal Steroid HormonesOlfactory Receptor NeuronsAnimalsHormonesMammalsMiceOlfactory BulbOlfactory MucosaProteinsGonadal Steroid HormonesHormonesProteinsAndrogensEstrogensOlfactionProgesteroneReceptorsSteroidogenesis

Identifiers

PMID36401093
PMCPMC9676892
OpenAlexW4309658771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.