ArticleCommunications biology2022
Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Local ancestry inference identifies robust evidence of selection in Neolithic Europe.Molecular biology and evolution · 2026Article
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- The genomic history of Streptococcus mutans from the Mesolithic until modern times.Genome biology · 2026Article
- An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.Cell genomics · 2025Article
- Projectile weapon injuries in the Riparo Tagliente burial (Veneto, Italy) provide early evidence of Late Upper Paleolithic intergroup conflict.Scientific reports · 2025Article
- Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans.Science (New York, N.Y.) · 2024Article
- Review
- Towards predicting the geographical origin of ancient samples with metagenomic data.Scientific reports · 2024Article
- Neandertal ancestry through time: Insights from genomes of ancient and present-day humans.bioRxiv : the preprint server for biology · 2024Article
- Inferring diet, disease and antibiotic resistance from ancient human oral microbiomes.Microbial genomics · 2024Review
- A Journey into the Evolution of Human Host-Oral Microbiome Relationship through Ancient Dental Calculus: A Scoping Review.Microorganisms · 2024Article
- Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.Scientific reports · 2024Article
- Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals.Scientific reports · 2024Article
- Spectra without stories: reporting 94% dark and unidentified ancient proteomes.Open research Europe · 2024Article
- Folate-producing bifidobacteria: metabolism, genetics, and relevance.Microbiome research reports · 2024Review
- Review
- Bioarchaeological and paleogenomic profiling of the unusual Neolithic burial from Grotta di Pietra Sant'Angelo (Calabria, Italy).Scientific reports · 2023Article
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Authors and funding
17 authors at 5 institutions in 3 countries.
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Abstract
Recent improvements in the analysis of ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and genetic diversity of our species. Here we present a multi-omics study, integrating metagenomic and proteomic analyses of dental calculus, and human ancient DNA analysis of the petrous bones of two post-Last Glacial Maximum (LGM) individuals from San Teodoro cave (Italy), to reconstruct their lifestyle and the post-LGM resettlement of Europe. Our analyses show genetic homogeneity in Sicily during the Palaeolithic, representing a hitherto unknown Italian genetic lineage within the previously identified Villabruna cluster. We argue that this lineage took refuge in Italy during the LGM, followed by a subsequent spread to central-western Europe. Analysis of dental calculus showed a diet rich in animal proteins which is also reflected on the oral microbiome composition. Our results demonstrate the power of this approach in the study of prehistoric humans and will enable future research to reach a more holistic understanding of the population dynamics and ecology.
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