Evidence map›Paper›PMID 36400896›Full record

ArticleScientific reports2022

Hypertensive disorders of pregnancy share common cfDNA methylation profiles.

Marialuigia Spinelli, Jarmila A Zdanowicz, Irene Keller, Pamela Nicholson, Luigi Raio, Sofia Amylidi-Mohr, Beatrice Mosimann, Daniel Surbek, Martin Mueller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Current Understanding on Hypertensive Disorders in Pregnancy.International journal of general medicine · 2026
    Review
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  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marialuigia Spinelli *Department of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland.
Jarmila A Zdanowicz *Department of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland.
Irene KellerDepartment for BioMedical Research, Swiss Institute of Bioinformatics, University Hospital, University of Bern, Bern, Switzerland.
Pamela NicholsonNext Generation Sequencing Platform, Institute of Genetics, Vetsuisse, University Hospital, University of Bern, Bern, Switzerland.
Luigi RaioDepartment of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland.
Sofia Amylidi-MohrDepartment of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland.
Beatrice MosimannDepartment of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland.
Daniel SurbekDepartment of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland.
Martin MuellerDepartment of Obstetrics and Gynecology, Department of Biomedical Research, University Hospital, Inselspital, University of Bern, Friedbuehlstrasse 19, 3010, Bern, Switzerland. martin.mueller@insel.ch.
University Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertensive disorders of pregnancy (HDP) contribute substantially to perinatal morbidity and mortality. Epigenetic changes point towards cardio-metabolic dysregulation for these vascular disorders. In early pregnancy, epigenetic changes using cell free DNA (cfDNA) are largely unexplored. We aimed to investigate these in HDP between 11 and 14 weeks of gestation by analysis of cfDNA methylation profiles in patients with hypertensive disorders. We identified patients without chronic hypertension but with subsequent development of preeclampsia (PE) (n = 11), with chronic hypertension (HT) but without PE development (n = 14), and lacking both PE and HT (n = 422). We matched patients according to PE risk factors into three groups (n = 5 each group): (1) PE: no HT but PE development, (2) HT: chronic hypertension but no PE and (3) Control: no PE or HT. We successfully optimized our cfDNA isolation process prior to whole genome bisulfite sequencing. Analysis of cfDNA methylation changes indicate a common predisposition in PE and HT groups, chiefly of maternal origin. Assessment of significant differentially methylated regions and annotated genes point towards a common cardiovascular predisposition in preeclampsia and hypertension groups in the first trimester. We postulate the pivotal role of the maternal cardiovascular system in HDP, which is already evident in the first trimester.

Indexed as

Cell-Free Nucleic AcidsHypertension, Pregnancy-InducedPre-EclampsiaFemaleHumansMethylationPregnancyPregnancy Trimester, FirstCell-Free Nucleic Acids

Identifiers

PMID36400896
PMCPMC9674847
OpenAlexW4309474155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.