ReviewEye (London, England)2023
Perineural invasion and perineural spread in periocular squamous cell carcinoma.
Review in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Prognostic and clinicopathological value of perineural invasion in colorectal cancer: a meta-analysis.Frontiers in oncology · 2026Pooled it
- Trigeminal-Facial Nerve Anatomical Connections and Their Clinical Value: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Intraoperative Molecular Imaging Can Detect Large Nerve Perineural Invasion: A Case Report.Head & neck · 2026Article
- A massive ocular surface squamous cell carcinoma: a case report.Journal of medical case reports · 2025Article
- Intracranial extension of parotid adenoid cystic carcinoma presenting as trigeminal neuralgia: A case report.Radiology case reports · 2025Article
- Normative data for dimensions of the frontal and infraorbital nerves.Eye (London, England) · 2025Article
- Perineural invasion as a neuro-immune niche in head and neck cancer: mechanisms of immune evasion and therapeutic implications.Frontiers in immunology · 2025Review
- Significance and mechanisms of perineural invasion in malignant tumors.Frontiers in oncology · 2025Review
- Review
- Use of Supra-eyebrow Skin as a Frontalis Myocutaneous Flap to Reconstruct Temporal Skin Defect and Treat Facial Nerve Palsy: A Report of Two Cases.Journal of plastic and reconstructive surgery · 2024Article
- Robotic assisted orbital surgery for resection of advanced periocular tumours - a case series report on the feasibility, safety and outcome.Eye (London, England) · 2024Article
- Risk Factors for Orbital Invasion in Malignant Eyelid Tumors, Is Orbital Exenteration Still Necessary?Journal of clinical medicine · 2024Article
- Statical Association between Clinical and Histopathological Parameters for Keratinocyte Carcinomas.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perineural invasion (PNI) in cutaneous squamous cell carcinoma (SCC) of the periocular region is a prognostic marker of adverse tumour outcomes. PNI carries a well-established risk of tumour recurrence, regional metastasis and higher likelihood of mortality. This review will explore and stratify the risks conferred by histological PNI parameters. The radiological features of perineural spread (PNS) and the imaging sequences that delineate these findings will also be highlighted. Surgical excision with en face margin control is the preferred technique for achieving histological clearance. Adjuvant radiotherapy improves treatment outcomes in the setting of concomitant high-risk features. For locally advanced or metastatic cutaneous SCC, immunotherapy represents a novel treatment alternative. This review will provide an algorithm for the diagnosis and management of periocular SCC with PNI and PNS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.