Evidence map›Paper›PMID 36400788›Full record

ArticleNature communications2022

Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

Viviane Tran, Sarah Nahlé, Amélie Robert, Inès Desanlis, Ryan Killoran, Sophie Ehresmann, Marie-Pier Thibault, David Barford, Kodi S Ravichandran, Martin Sauvageau and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Molecular regulation of myocyte fusion.Current topics in developmental biology · 2024
    Review
  9. Article
  10. Genes · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Viviane TranMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.
Sarah Nahlé *Montreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.
Amélie Robert *Montreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.
Inès DesanlisMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.ORCID 0000-0003-0411-717X
Ryan KilloranInstitute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3T 1J4, Canada.
Sophie EhresmannMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.ORCID 0000-0002-4171-7222
Marie-Pier ThibaultMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.
David BarfordMRC Laboratory of Molecular Biology, Cambridge, CB2 OQH, UK.ORCID 0000-0001-8810-950X
Kodi S RavichandranDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, 22908, VA, USA.ORCID 0000-0001-9049-1410
Martin SauvageauMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.
Matthew J SmithInstitute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3T 1J4, Canada.ORCID 0000-0003-2896-9350
Marie KmitaMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada.ORCID 0000-0003-4021-0478
Jean-François CôtéMontreal Clinical Research Institute (IRCM), Montreal, QC, H2W 1R7, Canada. jean-francois.cote@ircm.qc.ca.ORCID 0000-0001-7055-2642
Montreal Clinical Research Institute · CAInstitute for Research in Immunology and Cancer · CAMRC Laboratory of Molecular Biology · GBVIB-UGent Center for Inflammation Research · BE

Funding

Cancer Research UK 14109Cancer Research UK 24307Medical Research Council MC_UP_1201/6
6 · The paper itself

Abstract

Myoblast fusion is fundamental for the development of multinucleated myofibers. Evolutionarily conserved proteins required for myoblast fusion include RAC1 and its activator DOCK1. In the current study we analyzed the contribution of the DOCK1-interacting ELMO scaffold proteins to myoblast fusion. When Elmo1

Indexed as

MyoblastsSignal TransductionAdaptor Proteins, Signal TransducingAnimalsCytoskeletal ProteinsMiceMice, KnockoutMusclesAdaptor Proteins, Signal TransducingCytoskeletal ProteinsELMO1 protein, mouseElmo2 protein, mouse

Identifiers

PMID36400788
PMCPMC9674853
OpenAlexW4309327088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.