Evidence map›Paper›PMID 36400545›Full record

ReviewHematology/oncology clinics of North America2022

Allogeneic Transplant and Gene Therapy: Evolving Toward a Cure.

R AdeBisi Lawal, Mark C Walters, Courtney D Fitzhugh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hematology/oncology clinics of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

R AdeBisi LawalCellular and Molecular Therapeutics Branch, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 4-5140, Bethesda, MD 20892, USA; Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Mark C WaltersUniversity of California San Francisco Benioff Children's Hospital, 747 52nd Street, Oakland CA 94609, USA.
Courtney D FitzhughCellular and Molecular Therapeutics Branch, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6N240A, Bethesda, MD 20892, USA. Electronic address: fitzhughc@nhlbi.nih.gov.

Funding

Nonmyeloablative haploidentical peripheral blood stem cell transplantation in congenital anemiasZIAHL006211 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FITZHUGH, COURTNEY · 2016 to 2025
$19.4M
Clinical and genetic risk factors associated with adverse long-term health outcomes after curative therapies in individuals with sickle cell diseaseU01HL156620 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DEBAUN, MICHAEL R., FITZHUGH, COURTNEY D · 2021 to 2025
$4.1M
Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL006211NHLBI NIH HHS U01 HL156620
6 · The paper itself

Abstract

Curative therapies for sickle cell disease (SCD) include allogeneic human leukocyte antigen (HLA)- matched sibling and haploidentical hematopoietic cell transplant (HCT), gene therapy, and gene editing. However, comparative trial data that might facilitate selecting one curative therapy over another are unavailable. New strategies to decrease graft rejection and graft-versus-host disease (GVHD) risks are needed to expand haploidentical HCT. Myeloablative gene therapy and gene editing also has limitations. Herein, we review recent studies on curative therapies for SCD in the past 5 years.

Indexed as

Anemia, Sickle CellGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAllograftsGenetic TherapyHumansTransplantation ConditioningAllogeneic transplantGene editingGene therapyGraft versus host diseaseHaploidenticalHematopoietic cell transplantMatched sibling donorSickle cell disease

Identifiers

PMID36400545
PMCPMC9681017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.