Evidence map›Paper›PMID 36400379›Full record

ArticleNeuroImage2022

Endoscopic imaging of white matter fiber tracts using polarization-sensitive optical coherence tomography.

Damon DePaoli, Daniel C Côté, Brett E Bouma, Martin Villiger

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Damon DePaoliHarvard Medical School, Boston, MA 02115, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Daniel C CôtéCERVO Brain Research Center, Université Laval, Quebec City, Quebec G1E 1T2, Canada.
Brett E BoumaHarvard Medical School, Boston, MA 02115, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Martin VilligerHarvard Medical School, Boston, MA 02115, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: mvilliger@mgh.harvard.edu.
Harvard University · USUniversité Laval · CA

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Jacqueline Namati · 2012 to 2026
$22.4M
NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

Polarization sensitive optical coherence tomography (PSOCT) has been shown to image and delineate white matter fibers in a label-free manner by revealing optical birefringence within the myelin sheath using a microscope setup. In this proof-of-concept study, we adapt recent advancements in endoscopic PSOCT to perform depth-resolved imaging of white matter structures deep inside intact porcine brain tissue ex-vivo, through a small, rotational fiber probe. The probe geometry is comparable to microelectrodes currently used in neurosurgical interventions. The presented imaging system is mobile, robust, and uses biologically safe levels of optical radiation making it well suited for clinical translation. In neurosurgery, where accuracy is imperative, endoscopic PSOCT through a narrow-gauge fiber probe could provide intra-operative feedback on the location of critical white matter structures.

Indexed as

Tomography, Optical CoherenceWhite MatterAnimalsBirefringenceBrainMyelin SheathSwineBirefringenceIntracranial imagingOptical anisotropyOptical coherence tomographyPolarized light imaging

Identifiers

PMID36400379
PMCPMC9802682
OpenAlexW4309341169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.