Evidence map›Paper›PMID 36400004›Full record

ArticleMolecular cell2022

RASopathy mutations open new insights into the mechanism of BRAF activation.

Arvin C Dar, Donita C Brady

Open access · greenAbstract readComment
In one paragraph

Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Arvin C DarDepartment of Oncological Sciences, The Tisch Cancer Institute, Mount Sinai Centre for Therapeutic Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmaceutical Sciences, The Tisch Cancer Institute, Mount Sinai Centre for Therapeutic Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: arvin.dar@mssm.edu.
Donita C BradyDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bradyd@pennmedicine.upenn.edu.
Cancer Research Institute · USIcahn School of Medicine at Mount Sinai · US

Funding

Molecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and MetabolismR35GM124749 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Donita C Brady · 2017 to 2026
$4.6M
Targeting Oncogenic Ras-MAPK Signaling Complexes via the Scaffold KSRR01CA227636 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Arvin Dar · 2018 to 2026
$4.0M
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICSR01CA256480 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAR, ARVIN, GUCCIONE, ERNESTO · 2021 to 2025
$3.3M
A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal CancerR01CA258736 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DAR, ARVIN · 2021 to 2025
$3.2M
Unlocking the Chemical Space of Cancer-Associated PerturbationsR01CA280833 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BRADY, DONITA C, BURSLEM, GEORGE · 2022 to 2025
$2.2M
A Cytochrome P450 Therapeutic Space for TauopathiesR56AG066712 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAGAN, ROSS LEIGH, DAR, ARVIN · 2021 to 2021
$802k
NCI NIH HHS R01 CA227636NCI NIH HHS R01 CA256480NCI NIH HHS R01 CA258736NCI NIH HHS R01 CA280833NIA NIH HHS R56 AG066712NIGMS NIH HHS R35 GM124749
6 · The paper itself

Abstract

Spencer-Smith et al. (2022)

Indexed as

Proto-Oncogene Proteins B-rafMutationProtein DomainsProto-Oncogene Proteins B-raf

Identifiers

PMID36400004
PMCPMC9867872
OpenAlexW4309480049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.