ArticleRespiratory medicine2022
Urinary volatile organic compound metabolites and reduced lung function in U.S. adults.
Article in Respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Urinary volatile organic compounds as potential non-invasive markers for childhood obesity.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Analysis of 18 mercapturic acids in urine samples from the German Environmental Specimen Bank-tackling the data gap in the human biomonitoring of VOCs in Europe.Journal of exposure science & environmental epidemiology · 2026Article
- Mediating role of chronic inflammatory airway diseases in the association between volatile organic compounds exposure and depression.Medicine · 2026Article
- Lung microbiome predictors of epigenetic aging and potential associations with smoking and electronic cigarette use.Clinical epigenetics · 2026Article
- Diminished lung function mediating the associations between blood levels of volatile organic compounds and respiratory morbidity and mortality.Scientific reports · 2025Article
- Characterizing everyday exposure to volatile organic compounds and upper respiratory health effects.Scientific reports · 2025Article
- Disinfection byproducts in US drinking water and cancer mortality.International journal of environmental health research · 2025Article
- Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011-2018.Scientific reports · 2025Article
- Exposure to volatile organic compounds and chronic respiratory disease mortality, a case-cohort study.Respiratory research · 2025Article
- Volatile organic compounds exposure associated with skin cancer among U. S. adults: results from NHANES 2011-2018.Archives of dermatological research · 2025Article
- Urinary volatile organic compound metabolites and COPD among US adults: mixture, interaction and mediation analysis.Environmental health : a global access science source · 2024Article
- Article
- The urinary metabolites of volatile organic compounds and asthma in young children: NHANES 2011-2018.Heliyon · 2024Article
- From Mendel to multi-omics: shifting paradigms.European journal of human genetics : EJHG · 2024Article
- Prenatal exposure to replacement flame retardants and organophosphate esters and childhood adverse respiratory outcomes.Environmental research · 2024Article
- The association between exposure to volatile organic compounds and serum lipids in the US adult population.Lipids in health and disease · 2023Article
- Assessing volatile organic compounds exposure and chronic obstructive pulmonary diseases in US adults.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundVolatile organic compounds (VOCs) are associated with adverse respiratory outcomes at high occupational exposures. However, whether exposure levels found in the general population have similar effects is unknown.
methodsWe analyzed data on 1342 adult participants in the 2011-2012 National Health and Nutrition Examination Survey aged ≥18 years old who had urinary VOC metabolites and spirometry measurements available. Linear regression models adjusting for covariates were fitted to estimate the associations of VOC exposures levels and spirometry outcomes, while accounting for survey design and sampling weights to generate nationally representative estimates.
resultsThe urinary metabolites for xylene, acrylamide, acrolein, 1,3-butadiene, cyanide, toluene, 1-bromopropane, acrylonitrile, propylene oxide, styrene, ethylbenzene, and crotonaldehyde in our analysis were all detected in >75% of participants. Forced expiratory volume in 1 s (FEV
conclusionsThis is the first study of a representative sample of the U.S. adult population to reveal associations of acrylonitrile, propylene oxide, and styrene urinary metabolites with reduced lung function at non-occupational exposures. Results also support previous evidence of acrylamide and acrolein's association with adverse respiratory outcomes.
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