Evidence map›Paper›PMID 36399577›Full record

ArticleScience advances2022

Pointed-end processive elongation of actin filaments by

Elena Kudryashova, Ankita, Heidi Ulrichs, Shashank Shekhar, Dmitri S Kudryashov

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Life science alliance · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Actin isoform-specific interactions revealed byProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Effects of Bile on PathogenicBiomolecules · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. VopX, a novelmBio · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Antagonistic effects of actin-specific toxins onbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elena KudryashovaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-1646-1229
AnkitaDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-3978-4378
Heidi UlrichsDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-9096-2438
Shashank ShekharDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1494-0151
Dmitri S KudryashovDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1782-3305

Funding

Name Molecular mechanisms of bacterial toxins targeting actin cytoskeletonR01GM114666 · NIGMS · OHIO STATE UNIVERSITY · PI KUDRYASHOV, DMITRI · 2015 to 2025
$3.8M
MULTICOMPONENT MECHANOCHEMICAL REGULATION OF ACTIN FILAMENT END DYNAMICSR35GM143050 · NIGMS · EMORY UNIVERSITY · PI Shashank Shekhar · 2021 to 2026
$2.7M
NIGMS NIH HHS R01 GM114666NIGMS NIH HHS R35 GM143050
6 · The paper itself

Abstract

According to the cellular actin dynamics paradigm, filaments grow at their barbed ends and depolymerize predominantly from their pointed ends to form polar structures and do productive work. We show that actin can elongate at the pointed end when assisted by

Identifiers

PMID36399577
PMCPMC9674292

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.