ArticleScience immunology2022
OXPHOS promotes apoptotic resistance and cellular persistence in T
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 106 citations in OpenAlex.
- Disulfidptosis-based cancer therapy: Opportunity and challenge.Genes & diseases · 2027Review
- Metabolic profiling of CAR T-cells in patients reveals a shift toward amino acid-supported OXPHOS and informs transporter engineering.Research square · 2026Article
- Immunometabolic reprogramming in multiple sclerosis: from pathogenic amplifier to therapeutic target in neuroinflammation and remyelination.Inflammopharmacology · 2026Review
- Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TScience advances · 2026Article
- Succinate and lactate produced as conserved biomarkers through chronic and transient substrate-level phosphorylation: from microorganisms to cancer.Journal of bioenergetics and biomembranes · 2026Review
- Metabolic Perspective on Atherosclerosis: Macrophage Reprogramming and Novel Therapeutic Targets.Journal of the American Heart Association · 2026Review
- Contextualizing TNature reviews. Immunology · 2026Review
- Metabolic reprogramming of Th17/Treg imbalance in autoimmune thyroid diseases.Cell communication and signaling : CCS · 2026Review
- Development and validation of an oxidative phosphorylation based prognostic model revealing tumor progression and immune microenvironment in lung adenocarcinoma.Discover oncology · 2026Article
- Pyruvate kinase muscle 2 (PKM2) promotes CD4 T cell survival by regulating pyruvate oxidation during homeostasis and expansion.Science advances · 2026Article
- Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects.Molecular cancer · 2026Review
- Mitophagy-driven immune evasion in skin cancer: multidimensional regulatory networks and context-dependent therapeutic strategies-a narrative review.Frontiers in immunology · 2026Review
- Pim1 Serves as a Therapeutic Target for Inflammatory Arthritis via Mitochondrial Metabolism and Th17 Cell Differentiation.Research (Washington, D.C.) · 2026Article
- Metabolic checkpoints in the regulation of Th17 cells: implications for uveitis pathogenesis and therapy.Frontiers in immunology · 2026Review
- Article
- ALKBH7 and NLRP3 Co-Expression: A Potential Prognostic and Immunometabolic Marker Set in Breast Cancer Subtypes.International journal of molecular sciences · 2025Article
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- Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy.Molecular cancer · 2025Review
- Integrated Proteomics and Metabolomics Profiling Unravels Molecular Mechanisms Underlying Postmortem Meat Quality Between Two Ages and Muscle Types in Sansui Duck.Animals : an open access journal from MDPI · 2025Article
- A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells.Immunology and cell biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 3 institutions in 2 countries.
Hanna S HongGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1202-2808
Nneka E MbahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Mengrou ShanDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6385-9064
Kristen LoeselDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5916-8460
Lin LinDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6936-4150
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8556-7481
Luis O CorreaGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0345-5938
Anthony AndrenDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0385-527X
Jason LinDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9530-029X
Atsushi HayashiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Brian MagnusonDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5301-3302
Judy ChenGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5469-6619
Zhaoheng LiDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Yuying XieDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0703-7506
Daniel R GoldsteinInstitute of Gerontology, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6695-979X
Shannon A CartyGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2286-8014
Yu Leo LeiGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9868-9824
Anthony W OpipariDepartment of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Rafael J ArgüelloAix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0001-9785-3883
Ilona KryczekGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3130-2533
Nobuhiko KamadaGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1980-4178
Weiping ZouGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7952-3549
Luigi FranchiGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Costas A LyssiotisGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9309-6141
University of Michigan · USMichigan State University · USCentre National de la Recherche Scientifique · FR
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MRESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8MRestoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3MProteogenomics of Cancer Training ProgramT32CA140044 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, ARVIND, SARTOR, MAUREEN AGNES · 2010 to 2024
$3.9MTraining in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6MRegulatory T cells in cancer therapyR01CA244827 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2021 to 2025
$3.2MIntratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6MNCI NIH HHS P30 CA046592NCI NIH HHS R01 CA244827NCI NIH HHS R37 CA237421NCI NIH HHS T32 CA140044NIAID NIH HHS T32 AI007413NIDCR NIH HHS R01 DE026728NIDDK NIH HHS T32 DK094775NIDDK NIH HHS U24 DK097153
Abstract
T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (T
Indexed as
Oxidative PhosphorylationTumor MicroenvironmentAnimalsCell DifferentiationGlycolysisMiceMitochondria
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.