ArticlePloS one2022
A protocol paper for the MOTION Study-A longitudinal study in a cohort aged 60 years and older to obtain mechanistic knowledge of the role of the gut microbiome during normal healthy ageing in order to develop strategies that will improve lifelong health and wellbeing.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04199195 (A Longitudinal Study in a Cohort Aged 60 Years and Older to Obtain Mechanistic Knowledge of the Role of the Gut Microbiome During Normal Healthy Ageing in Order to Develop Strategies That Will Improve Lifelong Health and Wellbeing.), which is not on this map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Longitudinal Study in a Cohort Aged 60 Years and Older to Obtain Mechanistic Knowledge of the Role of the Gut Microbiome During Normal Healthy Ageing in Order to Develop Strategies That Will Improve Lifelong Health and Wellbeing.
Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Draft genome sequence of a human isolate ofMicrobiology resource announcements · 2026Article
- Expanding the diversity ofInternational journal of systematic and evolutionary microbiology · 2026Article
- The Role of the Gut Microbiome in Health and Disease in the Elderly.Current gastroenterology reports · 2024Review
- Aging Gut Microbiome in Healthy and Unhealthy Aging.Aging and disease · 2024Review
- Current insights into transcriptional role(s) for the nutraceuticalFrontiers in nutrition · 2024Review
- More than just a number: the gut microbiota and brain function across the extremes of life.Gut microbesReview
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAdvances in medicine and public health mean that people are living longer; however, a significant proportion of that increased lifespan is spent in a prolonged state of declining health and wellbeing which places increasing pressure on medical, health and social services. There is a social and economic need to develop strategies to prevent or delay age-related disease and maintain lifelong health. Several studies have suggested links between the gut microbiome and age-related disease, which if confirmed would present a modifiable target for intervention development. The MOTION study aims to determine whether and how changes in the gut microbiome are associated with physical and mental capacity. A comprehensive longitudinal multiparameter study such as this has not been previously undertaken.
methodsMOTION is a longitudinal prospective cohort study with a focus on gut health and cognitive function. 360 healthy individuals aged 60 years and older, living in East Anglia, UK will be recruited to the study, stratified into one of three risk groups (cohorts) for developing dementia based on their cognitive function. Participants will attend study appointments every six months over four years, providing stool and blood samples and a health questionnaire. Participants will also undergo physical measurements and cognitive tests at alternating appointments, and undergo Optical Coherence Tomography scans at 3 timepoints. Two subgroups of participants in the study will provide colonic tissue biopsies (n = ≥30 from each cohort), and brain imaging (n = 30) at two timepoints. DISCUSSION: This study will provide new insights into the gut-(microbiota)-brain axis and the relationship between age-associated changes in gut microbe populations and cognitive health. Such insights could help develop new microbe-based strategies to improve lifelong health and wellbeing.
trial registrationThis study is registered in the ClinicalTrials.gov Database with ID: NCT04199195 Registered: May 14, 2019.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.