Evidence map›Paper›PMID 36399373›Full record

ArticleJournal of medical Internet research2022

A Wolf in Sheep's Clothing: Reuse of Routinely Obtained Laboratory Data in Research.

L Malin Overmars, Michael S A Niemantsverdriet, T Katrien J Groenhof, Mark C H De Groot, Cornelia A R Hulsbergen-Veelken, Wouter W Van Solinge, Ruben E A Musson, Maarten J Ten Berg, Imo E Hoefer, Saskia Haitjema

Abstract read
In one paragraph

Article in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Comparison of estimated glomerular filtration rate equations on prediction of mortality, kidney failure and acute kidney injury.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

L Malin Overmars *Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-7086-0864
Michael S A Niemantsverdriet *Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0003-4985-478X
T Katrien J GroenhofDepartment of Obstetrics and Gynecology, St Antonius Hospital, Utrecht, Netherlands.ORCID 0000-0002-7315-3409
Mark C H De GrootCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-5764-5788
Cornelia A R Hulsbergen-VeelkenCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0003-4375-2221
Wouter W Van SolingeCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0003-2867-2581
Ruben E A MussonCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-1057-0977
Maarten J Ten BergCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-1252-0383
Imo E HoeferCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-8379-7814
Saskia HaitjemaCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID 0000-0001-5465-4868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electronic health records (EHRs) contain valuable data for reuse in science, quality evaluations, and clinical decision support. Because routinely obtained laboratory data are abundantly present, often numeric, generated by certified laboratories, and stored in a structured way, one may assume that they are immediately fit for (re)use in research. However, behind each test result lies an extensive context of choices and considerations, made by both humans and machines, that introduces hidden patterns in the data. If they are unaware, researchers reusing routine laboratory data may eventually draw incorrect conclusions. In this paper, after discussing health care system characteristics on both the macro and micro level, we introduce the reader to hidden aspects of generating structured routine laboratory data in 4 steps (ordering, preanalysis, analysis, and postanalysis) and explain how each of these steps may interfere with the reuse of routine laboratory data. As researchers reusing these data, we underline the importance of domain knowledge of the health care professional, laboratory specialist, data manager, and patient to turn routine laboratory data into meaningful data sets to help obtain relevant insights that create value for clinical care.

Indexed as

Decision Support Systems, ClinicalLaboratoriesDelivery of Health CareElectronic Health RecordsHumansResearch Personnelanalysisapplied data scienceclinicalclinical caredatadecisiondecision supportelectronic health recordslaboratorylaboratory datapatientpreprocessingresearchvalue

Identifiers

PMID36399373
PMCPMC9719056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.