Evidence map›Paper›PMID 36399165›Full record

ReviewJournal of neurology2023

Inclusion body myositis: from genetics to clinical trials.

Sara Nagy, Alaa Khan, Pedro M Machado, Henry Houlden

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Myopathies in clinical care: a focus on treatable causes.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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  10. Association betweenInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Sara NagyDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK. s.nagy@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6822-1609
Alaa KhanDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
Pedro M MachadoDepartment of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.
Henry HouldenDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
National Hospital for Neurology and Neurosurgery · GBUniversity Hospital of Basel · CHUniversity of Basel · CH

Funding

Medical Research Council G0601943Medical Research Council MR/S005021/1Medical Research Council MR/S01165X/1Medical Research Council Centre for Medical Mycology G0601943Medical Research Council Centre for Medical Mycology MR/S005021/1Medical Research Council Centre for Medical Mycology MR/S01165X/1
6 · The paper itself

Abstract

Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited. This review gives an overview of the disease and focuses on the current genetic knowledge and potential therapeutic implications.

Indexed as

MyositisMyositis, Inclusion BodyDisease ProgressionHumansClinical trialsGene therapyGenetic susceptibilityHereditary inclusion body myositisInflammationNeurodegenerationSporadic inclusion body myositis

Identifiers

PMID36399165
PMCPMC9971047
OpenAlexW4309366060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.