ArticleChembiochem : a European journal of chemical biology2023
Reaction Pathways for the Enzymatic Degradation of Poly(Ethylene Terephthalate): What Characterizes an Efficient PET-Hydrolase?
Article in Chembiochem : a European journal of chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Isosteric Engineering of Enzymes: Overcoming Activity-Stability Trade-Offs by Site-Selective CH → N Substitutions.Angewandte Chemie (International ed. in English) · 2026Article
- Structure-Guided Extremophile Genome Mining Expands the PETase Landscape and Reveals PET-Hydrolysing True Lipase Lineages.Microbial biotechnology · 2026Article
- Dissolution-Precipitation Using Natural Terpenes as Pretreatment for PET Enzymatic Depolymerization.ACS omega · 2026Article
- Article
- Biological Degradation of Phthalates: From Bioremediation to Plastic Waste Valorization.ChemSusChem · 2026Review
- Toxic effects of microplastics in aquatic environments and the pathways to sustainable management.RSC advances · 2026Review
- EngineeringiScience · 2026Article
- Dynamic shift of internal electric field accelerates enzymatic polyethylene terephthalate depolymerization.Communications chemistry · 2026Article
- Microbial plastic degradation: enzymes, pathways, challenges, and perspectives.Microbiology and molecular biology reviews : MMBR · 2025Review
- Selective Modification of the Product Profile of Biocatalytic Hydrolyzed PET via Product-Specific Medium Engineering.ChemSusChem · 2025Article
- In-Situ Product Removal for the Enzymatic Depolymerization of Poly(ethylene terephthalate) via a Membrane Reactor.ChemSusChem · 2025Article
- Plastic degradation by enzymes from uncultured deep sea microorganisms.The ISME journal · 2025Article
- Increased cytoplasmic expression of PETase enzymes in E. coli.Microbial cell factories · 2024Article
- Article
- Identification and expression of MarCE, a marine carboxylesterase with synthetic ester-degrading activity.Microbial biotechnology · 2024Article
- The reaction mechanism of the Ideonella sakaiensis PETase enzyme.Communications chemistry · 2024Article
- Natural diversity screening, assay development, and characterization of nylon-6 enzymatic depolymerization.Nature communications · 2024Article
- Enrichment of native plastic-associated biofilm communities to enhance polyester degrading activity.Environmental microbiology · 2023Article
- Assessment of Four Engineered PET Degrading Enzymes Considering Large-Scale Industrial Applications.ACS catalysis · 2023Article
- Microbial Enzyme Biotechnology to Reach Plastic Waste Circularity: Current Status, Problems and Perspectives.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioprocessing of polyester waste has emerged as a promising tool in the quest for a cyclic plastic economy. One key step is the enzymatic breakdown of the polymer, and this entails a complicated pathway with substrates, intermediates, and products of variable size and solubility. We have elucidated this pathway for poly(ethylene terephthalate) (PET) and four enzymes. Specifically, we combined different kinetic measurements and a novel stochastic model and found that the ability to hydrolyze internal bonds in the polymer (endo-lytic activity) was a key parameter for overall enzyme performance. Endo-lytic activity promoted the release of soluble PET fragments with two or three aromatic rings, which, in turn, were broken down with remarkable efficiency (k
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.