Evidence map›Paper›PMID 36398889›Full record

ArticleGut microbes

Ding-Jia-Cheng Jia, Qi-Wen Wang, Ying-Ying Hu, Jia-Min He, Qi-Wei Ge, Ya-Dong Qi, Lu-Yi Chen, Ying Zhang, Li-Na Fan, Yi-Feng Lin and 9 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07191405 (The Efficacy and Safety of Chemotherapy and Immune Therapy Combined With Lactobacillus Johnsonii in Patients With Metastatic or Locally Advanced Unresectable or Recurrent EGFR/ALK Wild-type Adenocarcinoma Non-small Cell Lung Cancer), which is not on this map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07191405 nanot yet recruitingnot on this map

The Efficacy and Safety of Chemotherapy and Immune Therapy Combined With Lactobacillus Johnsonii in Patients With Metastatic or Locally Advanced Unresectable or Recurrent EGFR/ALK Wild-type Adenocarcinoma Non-small Cell Lung Cancer (NSCLC), PD-L1 Positive (CPS≥1) Triple-negative Breast Cancer (TNBC) and HER2-negative Gastric or Gastro-oesophageal Junction Adenocarcinoma: a Multicenter, Randomized, Double-blind, Clinical Trial.

TypeinterventionalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2025 to 2026Enrolled156ConditionsImmunotherapy, ChemotherapyArmsoral Lactobacillus johnsonii (1×10¹¹ CFU, twice daily), Placebo
3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 175 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Journal of agricultural and food chemistry · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Safety and immunostimulatory potential evaluation of Limosilactobacillus fermentum isolated from millet-based fermented food in mice.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Ding-Jia-Cheng JiaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0002-0089-4580
Qi-Wen WangInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Ying-Ying HuInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Jia-Min HeInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Qi-Wei GeDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Ya-Dong QiInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Lu-Yi ChenInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Ying ZhangInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Li-Na FanDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yi-Feng LinDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yong SunDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yao JiangDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Lan WangInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Yan-Fei FangInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Hui-Qin HeDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Xiong-E PiInstitute of Plant Protection and Microbiology, Zhejiang Academy of Agriculture Sciences, Hangzhou, China.
Wei LiuInstitute of Plant Protection and Microbiology, Zhejiang Academy of Agriculture Sciences, Hangzhou, China.ORCID 0000-0002-3343-4652
Shu-Jie ChenInstitution of Gastroenterology, Zhejiang University, Hangzhou, China.
Liang-Jing WangDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0001-8227-8855
Sir Run Run Shaw Hospital · CNSecond Affiliated Hospital of Zhejiang University · CNInstitute of Plant Protection · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imbalance of gut microbiota homeostasis is related to the occurrence of ulcerative colitis (UC), and probiotics are thought to modulate immune microenvironment and repair barrier function. Here, in order to reveal the interaction between UC and gut microbiota, we screened a new probiotic strain by 16S rRNA sequencing from Dextran Sulfate Sodium (DSS)-induced colitis mice, and explored the mechanism and clinical relevance.

Indexed as

ColitisColitis, UlcerativeGastrointestinal MicrobiomeLactobacillus johnsoniiToll-Like Receptor 1AnimalsAnti-Inflammatory AgentsDextran SulfateInterleukin-10MacrophagesMiceRNA, Ribosomal, 16SSTAT3 Transcription FactorToll-Like Receptor 2Anti-Inflammatory AgentsDextran SulfateInterleukin-10RNA, Ribosomal, 16SStat3 protein, mouseSTAT3 Transcription FactorTlr2 protein, mouseToll-Like Receptor 1Toll-Like Receptor 2IL-10Lactobacillus johnsoniiMacrophagesSTAT3Ulcerative colitis

Identifiers

PMID36398889
PMCPMC9677986
OpenAlexW4309473602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.