Evidence map›Paper›PMID 36398873›Full record

ArticleeLife2022

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

Chao Tan, Giovanni de Nola, Claire Qiao, Cordelia Imig, Richard T Born, Nils Brose, Pascal S Kaeser

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  10. Review
  11. Frequency of Spontaneous Neurotransmission at Individual Boutons Corresponds to the Size of the Readily Releasable Pool of Vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Molecular definition of distinct active zone protein machineries for CabioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Chao TanDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0003-3787-0336
Giovanni de NolaDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Claire QiaoDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0003-2084-2478
Cordelia ImigDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7351-8706
Richard T BornDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0003-4360-427X
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany.
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-1558-1958
Harvard University · USMax Planck Institute for Multidisciplinary SciencesUniversity of Copenhagen · DK

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Dissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related ResearchR01MH113349 · NIMH · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$6.1M
Molecular Dissection of Active Zone Functions in Neurotransmitter ReleaseR01NS083898 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2014 to 2026
$5.9M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8M
NICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH113349NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS083898
6 · The paper itself

Abstract

Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca

Indexed as

SynapsesSynaptic VesiclesAnimalsCarrier ProteinsMiceNeuronsPresynaptic TerminalsSynaptic TransmissionCarrier Proteinsactive zonecell biologyfusion competencemousemunc13neurosciencereadily releasable poolsynapsesynaptic vesicle priming

Identifiers

PMID36398873
PMCPMC9822248
OpenAlexW4309361073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.