ArticleBJOG : an international journal of obstetrics and gynaecology2023
Association between marked fetal heart rate variability and neonatal acidosis: A prospective cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Development and validation of a machine learning-based early prediction model for fetal acidosis in vaginal deliveries.Scientific reports · 2026Article
- Association of normal-range fetal heart rate variations during labor with umbilical cord arterial blood gas parameters and neonatal outcomes: A cross-sectional study.International journal of reproductive biomedicine · 2025Article
- Fetal Heart Rate Analysis in Pregnancies Complicated by Gestational Diabetes Mellitus: A Prospective Multicentre Observational Study.BJOG : an international journal of obstetrics and gynaecology · 2025Observational
- Suppressed or increased fetal heart rate variability: Which is more associated with intrapartum fetal compromise?Acta obstetricia et gynecologica Scandinavica · 2024Article
- Increased heart rate variability during evolving fetal hypoxia: Be careful during pushing efforts.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Association between marked fetal heart rate variability and neonatal acidosis: A prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2023Article
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7 authors.
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Abstract
objectiveTo assess the association between marked variability in fetal heart rate (FHR) and neonatal acidosis.
designBicentric prospective cohort study.
settingFrom January 2019 to December 2019, in two French tertiary care maternity units. POPULATION: Women in labour at ≥37 weeks of gestation, with continuous FHR monitoring until delivery and with the availability of umbilical arterial pH. Women with intrauterine fetal death or medical termination, multiple pregnancies, non-cephalic presentation or planned caesarean delivery were excluded.
methodsThe exposure was marked variability in FHR in the 60 minutes before delivery, defined as a variability greater than 25 beats per minute, with a minimum duration of 1 minute. To assess the association between marked variability and neonatal acidosis, we used multivariable modified Poisson regression modelling. We then conducted subgroup analyses according to the US National Institute of Child Health and Human Development (NICHD) category of the associated fetal heart rate.
main outcome measuresNeonatal acidosis, defined as an umbilical artery pH of ≤7.10.
resultsAmong the 4394 women included, 177 (4%) had marked variability in fetal heart rate in the 60 minutes before delivery. Acidosis occurred in 6.0% (265/4394) of the neonates. In the multivariable analysis, marked variability was significantly associated with neonatal acidosis (aRR 2.30, 95% CI 1.53-3.44). In subgroup analyses, the association between marked variability and neonatal acidosis remained significant in NICHD category-I and category-II groups.
conclusionsMarked variability was associated with a twofold increased risk of neonatal acidosis.
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