Evidence map›Paper›PMID 36398250›Full record

ArticleAmerican journal of translational research2022

miR-204-3p downregulates KRT16 and promotes corneal repair in tree shrew fungal keratitis model.

Jie Jia, Yuanyuan Han, Liangzi Jin, Caixia Lu, Wenguang Wang, Pinfen Tong, Na Li, Xiaomei Sun, Wenpeng Gu, Jiejie Dai

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jie JiaInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Yuanyuan HanInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Liangzi JinInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Caixia LuInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Wenguang WangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Pinfen TongInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Na LiInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Xiaomei SunInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Wenpeng GuInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Jiejie DaiInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCorneal repair is critical for the treatment and recovery of corneal injuries. However, the molecular mechanism underlying corneal repair remains unclear.

methodsA tree shrew model of corneal fungal infection was established by injecting

resultsmiR-204-3p expression was significantly downregulated, while KRT16 expression was significantly upregulated after

conclusionsIn this study, we report for the first time that miR-204-3p and KRT16 influence the repair of corneal injury. In addition, their effects on the repair of corneal injury were studied in a tree shrew model, providing an experimental basis for the study of pathogenesis of human fungal keratitis.

Indexed as

animal modelfungal keratitisKRT16miR-204-3pTree shrew

Identifiers

PMID36398250
PMCPMC9641470
OpenAlexW4309413435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.