ArticleAmerican journal of translational research2022
Correlation of synovial tissue protein abundance with menopause in osteoarthritis.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- A Thematic Narrative Review of Osteoarthritis Risk Factors Across the Female Life Course.International journal of molecular sciences · 2026Review
- Progress in multi-omics studies of osteoarthritis.Biomarker research · 2025Review
- Burden of knee osteoarthritis in China and globally from 1992 to 2021, and projections to 2030: a systematic analysis from the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA) is a common articular disorder. Epidemiologic surveys show a higher prevalence of OA in women than men and that morbidity is higher during menopause. We aimed to explore whether menopause influences the clinical recovery of a knee joint following OA and injury, and identify associated mechanisms by analyzing the proteomic profile of synovial tissue (ST) samples.
methodsRoutine blood examination and hormone level tests were conducted before surgery. ST samples from eight participants were collected intraoperatively for proteomic analysis. One day before and one month after the surgery, we assessed various aspects of function in the affected knee including the with Visual Analog Score (VAS), Lysholm, The Western Ontario, and McMaster Universities Osteoarthritis Index (WOMAC) scores. The relationships between proteomic data, estrogen levels, and affected knee function were compared and analyzed. This was a retrospective study.
resultMenopause was associated with the clinical outcomes of knee OA and knee injuries. ST proteomic data identified that 80 proteins in premenopausal OA females were significantly different from menopausal OA females. In addition, 100 proteins were significantly different between premenopausal OA females and premenopausal injured females.
conclusionsAge and menopause showed a positive correlation with the protein profile of ST from OA or knee injury female patients, indicating that the protein components might be affected by menopause. Postoperative clinical outcomes were affected by menopause. We conclude that menopause may, in part, regulate knee joint function by altering ST protein expression.
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