Peripheral iridectomy for glaucoma is more effective than compound trabeculectomy and significantly reduces Hcy and hs-CRP levels.

Yanlin Gao, Qi Zhao, Haoqing Li, Jingmin Li, Peiyu Li

Open access · greenAbstract read

In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 78% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yanlin GaoTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Clinical College of Ophthalmology, Tianjin Medical University, Nankai University Eye Hospital Tianjin, China.

Qi ZhaoDepartment of Ophthalmology, The Second Hospital of Dalian Medical University Dalian, China.

Haoqing LiTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Clinical College of Ophthalmology, Tianjin Medical University, Nankai University Eye Hospital Tianjin, China.

Jingmin LiDepartment of Ophthalmology, The Second Hospital of Dalian Medical University Dalian, China.

Peiyu LiDepartment of Ophthalmology, The Second Hospital of Dalian Medical University Dalian, China.

Dalian Medical University · CNTianjin Medical University Eye Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the efficacy of peripheral iridectomy and compound trabeculectomy for glaucoma and the changes in homocysteine (Hcy) and hypersensitivity C-reactive protein (hs-CRP) levels before and after treatment.

methodsAltogether 104 patients with primary angle-closure glaucoma who were admitted from February 2020 to January 2022 were enrolled in this study for a retrospective analysis. Among them, 49 cases treated by peripheral iridectomy were considered as the research group, and 55 treated by compound trabeculectomy were seen as the control group. The intraocular pressure (IOP), vision, anterior chamber depth (ACD), surgical efficiency and complications before and after surgery was compared between the two groups of patients. Patients' venous blood was collected before and after treatment to test the Hcy and hs-CRP levels, and the relationship between the levels and treatments was analyzed. The ROC curves of Hcy and hs-CRP diagnostic efficacy after treatment were also plotted, and the relationship between Hcy and hs-CRP and patient outcomes was tested by Pearson correlation coefficient.

resultsThere were no marked differences in IOP, vision and ACD between the two groups before surgery (P>0.05). After surgery, the IOP was dramatically lower, and ACD and vision were dramatically higher in the research group than those in the control group (P<0.01). Compared to the control group, the treatment success rate in the research group was markedly higher, and the incidence of adverse reactions was lower. There was no difference in Hcy and hs-CRP levels before surgery between the two groups (P>0.05). After surgery both Hcy and hs-CRP levels decreased (P<0.05), and levels in the research group were lower than in the control group (P<0.05). Patients with better outcomes had lower postoperative Hcy and hs-CRP levels (P<0.05). ROC curves of the diagnostic efficacy of Hcy and hs-CRP after treatment manifested that the areas under the curve were >0.7. Both Hcy and hs-CRP levels were found to be negatively correlated with patient outcomes by Pearson correlation coefficient (P<0.001).

conclusionThe efficacy of peripheral iridotomy for glaucoma is better than that of compound trabeculectomy. Monitoring Hcy and hs-CRP levels in patients before and after surgery can effectively assess clinical outcomes as well as the safety of the procedure.

Indexed as

compound trabeculectomyglaucomaHcyhs-CRPPeripheral iridectomy

Identifiers

PMID36398238

PMCPMC9641481

OpenAlexW4309410060

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.