ArticleAmerican journal of translational research2022
Latent class trajectory modelling: impact of changes in model specification.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Trajectories of post-traumatic stress disorder symptoms and risk-protective factors in recently resettled refugees in the United States.The International journal of social psychiatry · 2025Trial
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- Association of first-trimester inflammatory markers with gestational diabetes mellitus subtypes and patterns: a cohort study.Journal of endocrinological investigation · 2026Article
- Predictive value of cholesterol, high-density lipoprotein, and glucose index-obesity-derived index for stroke: a cohort study.Lipids in health and disease · 2026Article
- Insomnia symptom trajectories and incident cardiovascular disease in older adults: a longitudinal cohort study.Heart (British Cardiac Society) · 2026Article
- Open and closed loop differential target multiplexed spinal cord stimulation in patients with persistent spinal pain syndrome type II: protocol for a one year European multicenter cohort study (ENDLESS).Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Associations of Proteinuria Trajectories with Kidney Failure and Death in Individuals with CKD.Kidney360 · 2025Article
- Clinical and Psychosocial Stress Correlates of Self-Harm in Women: A Retrospective Cohort Study in the Forensic Mental Health Setting.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Initial and Longitudinal Trajectories in Hemoglobin Levels Predict the Prognosis of Patients With Premature Rupture of Membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- Are Children's Externalizing and Internalizing Behaviours at 5 Years Predicted by Maternal Perinatal Depression Trajectory Profiles?Children (Basel, Switzerland) · 2025Article
- Longitudinal trajectories of sexual behavior and incident hepatitis C reinfection among men who have sex with men with HIV.PloS one · 2025Article
- Article
- Neck circumference, waist-to-height ratio, Chinese visceral adiposity index and incident heart failure.Nutrition journal · 2024Article
- Article
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Article
- Opportunities and challenges for biomarker discovery using electronic health record data.Trends in molecular medicine · 2023Review
- Person, Population, Mechanism. Three Main Branches of Psychological Science.Journal for person-oriented research · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Latent class trajectory models (LCTMs) are often used to identify subgroups of patients that are clinically meaningful in terms of longitudinal exposure and outcome, e.g. drug response patterns. These models are increasingly applied in medicine and epidemiology. However, in many published studies, it is not clear whether the chosen models, where subgroups of patients are identified, represent real heterogeneity in the population, or whether any associations with clinically meaningful characteristics are accidental. In particular, we note an apparent over-reliance on lowest AIC or BIC values. While these are objective measures of goodness of fit, and can help identify the optimal number of subgroups, they are not sufficient on their own to fully evaluate a given trajectory model. Here we demonstrate how longitudinal latent class models can substantially change by making small modifications in model specification, and the impact of this on the relationship to clinical outcomes. We show that the predicted trajectory patterns and outcome probabilities differ when pre-specified cubic versus linear shapes are tested on the same data. However, both could be interpreted to be the "correct" model. We emphasise that LCTMs, like all unsupervised approaches, are hypotheses generating, and should not be directly implemented in clinical practice without significant testing and validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.