Evidence map›Paper›PMID 36397827›Full record

ArticleClinical psychology in Europe2020

The Effect of Television and Print News Stories on the Nocebo Responding Following a Generic Medication Switch.

Kate MacKrill, Greg D Gamble, Keith J Petrie

Abstract readNews
In one paragraph

Article in Clinical psychology in Europe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The Nocebo Effect.Annual review of pharmacology and toxicology · 2024
    Review
  4. Article
  5. Health Scares: Tracing Their Nature, Growth and Spread.Clinical psychology in Europe · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kate MacKrillDepartment of Psychological Medicine, University of Auckland, Auckland, New Zealand.
Greg D GambleDepartment of Medicine, University of Auckland, Auckland, New Zealand.
Keith J PetrieDepartment of Psychological Medicine, University of Auckland, Auckland, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Following a nationwide switch to a generic antidepressant, a series of negative media stories publicised the experiences of some patients having side effects following the switch. This occurred first in print media and five months later it occurred again in television news. In this study we examined the effect of television news stories compared to print stories on adverse drug reaction reporting. We also examined the change in reporting rate of specific side effects mentioned in the TV news bulletins. Method: Using an interrupted time series analysis of data from a national adverse reactions database, we compared the number of adverse reaction reports after the print and television coverage and the changes in reporting rate of side effects mentioned and not mentioned in TV news stories. Results: We found a significant increase in adverse reaction reports following TV news items that discussed patients' reports of side effects following the medication switch (interruption effect = 73.25, p = .046). The reporting rate of symptoms mentioned in the TV news bulletins also increased, in particular suicidal thoughts (interruption effect = 23.60, p = .031). The effect of TV stories on adverse reaction reports was 211% greater than the print articles. Conclusions: Television stories have a much stronger effect than print media on nocebo responding and specific symptoms mentioned in the bulletins have a direct influence on the type of side effects subsequently reported. Media guidelines should be developed to reduce the negative public health effects of media coverage following medication switches.

Indexed as

generic medicinemedication switchnocebo effectprint mediaside effectstelevision media

Identifiers

PMID36397827
PMCPMC9645488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.