Evidence map›Paper›PMID 36397653›Full record

ArticleAging cell2022

Stress induced aging in mouse eye.

Qianlan Xu, Cezary Rydz, Viet Anh Nguyen Huu, Lorena Rocha, Claudia Palomino La Torre, Irene Lee, William Cho, Mary Jabari, John Donello, David C Lyon and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 54 citations in OpenAlex.

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  16. Review
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  18. Modeling complex age-related eye disease.Progress in retinal and eye research · 2024
    Review
  19. Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Qianlan XuDepartment of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Cezary RydzDepartment of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Viet Anh Nguyen HuuViterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Lorena RochaViterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Claudia Palomino La TorreViterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Irene LeeDepartment of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
William ChoDepartment of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Mary JabariViterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
John DonelloDepartment of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
David C LyonDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, California, USA.
Robert T BrookeEpigenetic Clock Development Foundation, Torrance, California, USA.
Steve HorvathEpigenetic Clock Development Foundation, Torrance, California, USA.ORCID https://orcid.org/0000-0002-4110-3589
Robert N WeinrebViterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Won-Kyu JuViterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Andrzej FoikDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, California, USA.
Dorota Skowronska-KrawczykDepartment of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, School of Medicine, University of California, Irvine, California, USA.ORCID https://orcid.org/0000-0002-5758-4225
University of California, Irvine · USUniversity of San Diego · USEpigenetix (United States) · US

Funding

Mitochondrial Protection in Glaucomatous Optic NeuropathyR01EY031697 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JU, WONKYU, PERKINS, GUY A · 2020 to 2023
$2.7M
Transfer: Molecular Mechanisms of GlaucomaR01EY027011 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SKOWRONSKA-KRAWCZYK, DOROTA · 2017 to 2022
$2.3M
NEI NIH HHS EY027011NEI NIH HHS EY031697NEI NIH HHS R01 EY027011NEI NIH HHS R01 EY031697
6 · The paper itself

Abstract

Aging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecular impact of aging on response to stress in retina is very limited; therefore, we developed a new mouse model to approach this question experimentally. Here we show that susceptibility to response to stress increases with age and is primed on chromatin level. We demonstrate that ocular hypertension activates a stress response that is similar to natural aging and involves activation of inflammation and senescence. We show that multiple instances of pressure elevation cause aging of young retina as measured on transcriptional and DNA methylation level and are accompanied by local histone modification changes. Our data show that repeated stress accelerates appearance of aging features in tissues and suggest chromatin modifications as the key molecular components of aging. Lastly, our work further emphasizes the importance of early diagnosis and prevention as well as age-specific management of age-related diseases, including glaucoma.

Indexed as

GlaucomaIntraocular PressureAgingAnimalsChromatinDisease Models, AnimalMiceRetinal Ganglion CellsChromatinagingIOPretinal ganglion cellssenescencestress response

Identifiers

PMID36397653
PMCPMC9741506
OpenAlexW4309361329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.