ArticleJournal of clinical laboratory analysis2022
Gastrointestinal Langerhans cell histiocytosis with unifocal, single-system involvement in adults: Cases report and literature review.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Adult Langerhans Cell Histiocytosis Presenting as an Isolated Rectal Polyp and Hematochezia.Cureus · 2026Article
- Clinicopathological features of gastric Langerhans cell histiocytosis and a literature review.Journal of clinical and experimental hematopathology : JCEH · 2026Review
- Isolated gastric Langerhans cell histiocytosis: a case report and literature review.Frontiers in oncology · 2026Article
- Advances in the diagnosis and management of pediatric Langerhans cell histiocytosis and Rosai-Dorfman disease: therapies, biomarkers, and response assessment.Hematology. American Society of Hematology. Education Program · 2025Review
- Tonsillar langerhans cell sarcoma with gastrointestinal metastasis: a rare case report.AME case reports · 2025Article
- Case Report: Systematic endoscopic characterization of synchronous esophageal, gastric, and colorectal involvement in multisystem Langerhans cell histiocytosis.Frontiers in medicine · 2025Article
- Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review.Journal of hematopathology · 2024Review
- Intestinal Langerhans cell histiocytosis presenting with symptoms similar to inflammatory bowel disease: a case report.Pathology oncology research : POR · 2024Article
- Gastrointestinal Langerhans cell histiocytosis with unifocal, single-system involvement in adults: Cases report and literature review.Journal of clinical laboratory analysis · 2022Article
- Solitary gastric langerhans cell histiocytosis treated by endoscopic submucosal dissection: A case report and literature review.Science progressReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLangerhans cell histiocytosis (LCH) is characterized by unifocal, multifocal single-system, or multi-system disease that occurs in all age groups, while it primarily attacks pediatric patients. Solitary gastrointestinal (GI) LCH in adults is exceedingly rare, so we aimed to investigate GI LCH in adults with unifocal single-system involvement and clarified the clinicopathologic characteristics of this disease.
methodsTwo cases of solitary GI LCH in adults were presented, and the clinicopathologic features of this diagnosis in the literature were reviewed.
resultsThe main diagnostic feature of LCH is the morphologic identification of the characteristic Langerhans cells with prominent nuclear grooves and abundant eosinophilic cytoplasm, accompanied by a variable number of lymphocytes, eosinophils, and plasma cells. The distinctive cells expressed S100, CD1a, and langerin (CD207) on immunohistochemistry. BRAF V600E mutations were detected in the two patients.
conclusionsGastrointestinal Langerhans cell histiocytosis in adults with unifocal, single-system involvement is extremely rare. Most patients were asymptomatic and usually a small solitary polyp in GI tract can be observed under routine endoscopy. Although the overall prognosis of unifocal single-system LCH is favorable, long-term follow-up is still necessary to rule out systemic disease.
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