Evidence map›Paper›PMID 36397091›Full record

ArticleChild and adolescent psychiatry and mental health2022

Examining how and why polygenic dopamine composite levels moderate adolescents' vulnerability to peer victimization.

Yemiao Gao, Yuke Xiong, Xia Liu, Jinmeng Liu, Jinwen Li, Hui Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yemiao GaoInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, China.
Yuke XiongCollaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal University, Beijing, China.
Xia LiuInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, China. liuxia@bnu.edu.cn.ORCID http://orcid.org/0000-0003-1136-4742
Jinmeng LiuInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, China.
Jinwen LiInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, China.
Hui WangInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, China.
Beijing Normal University · CN

Funding

National Natural Science Foundation of China 31900772
6 · The paper itself

Abstract

Extensive literature documents that dopaminergic genes play an important role in the link between adverse environments and adolescents' problem behavior. However, little is known about the potential mechanism underlying adolescents' vulnerability to peer victimization. The current study examined the effect of the interplay between a polygenic dopamine composite (i.e., COMT Val158Met and DRD2-141C Ins/Del polymorphisms) and peer victimization on adolescents' externalizing problems as well as the mediating role of emotion dysregulation in the interactive effects in a sample of 393 Chinese adolescents (Mean age = 14.71 years; 50.1% girls). A significant moderation of dopaminergic genetic composite was observed in girls but not in boys. In addition, emotion dysregulation partially explained the moderating effect of dopaminergic genes. Specifically, girls with genic composite indexing low dopamine activity reported a higher level of emotion dysregulation when faced with more peer victimization. More difficulties with emotion regulation, in turn, predicted more pronounced externalizing problems in girls. This study underscores polygenic underpinnings of adolescent vulnerability to negative peer experiences and suggests the importance of considering sex differences when investigating genic influence on the relationship between adverse environments and externalizing problems.

Indexed as

Dopamine genesEmotion dysregulationExternalizing problemsPeer victimization

Identifiers

PMID36397091
PMCPMC9670640
OpenAlexW4309268414

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.