Evidence map›Paper›PMID 36396849›Full record

SynthesisJournal of nephrology2022

Systematic review of pregnancy and renal outcomes for women with chronic kidney disease receiving assisted reproductive therapy.

Mahua Bhaduri, Rouvick M Gama, T Copeland, Alokya Balagamage, Priya Patel, Emily Warmington, Ippokratis Sarris, Kypros Nicholaides, Kate Bramham

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Impact of CKD on Female Reproductive Hormones.Kidney international reports · 2025
    Article
  5. Overview of ADPKD in Pregnancy.Kidney international reports · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Female Infertility in Chronic Kidney Disease.Diagnostics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mahua BhaduriKing's Fertility, London, UK. mahua.bhaduri@kingsfertility.co.uk.ORCID 0000-0003-4404-768X
Rouvick M GamaDepartment of Women and Children's Health, King's College London, London, UK.
T CopelandKing's Fertility, London, UK.
Alokya BalagamageKing's College London School of Medicine, London, UK.
Priya PatelKing's College London School of Medicine, London, UK.
Emily WarmingtonCollege of Medicine and Dental Sciences, University of Birmingham, Birmingham, England.
Ippokratis SarrisKing's Fertility, London, UK.
Kypros NicholaidesFetal Medicine Research Institute, Harris Birthright Centre, King's College Hospital, London, UK.
Kate BramhamDepartment of Women and Children's Health, King's College London, London, UK.
King's College London · GBBirmingham Dental Hospital · GBHarris Birthright Research Centre for Fetal Medicine · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs awareness around infertility is increasing among patients with chronic kidney disease (CKD), ever more of them are seeking Assisted Reproductive Technology (ART). Our aim was to perform a systematic review to describe obstetric and renal outcomes in women with CKD following ART.

methodsThe following databases were searched from 1946 to May 2021: (1) Cochrane Central Register of Controlled Trials (CENTRAL), (2) Cumulative Index to Nursing and Allied Health Literature (CINAHL), (3) Embase and (4) MEDLINE.

resultsThe database search identified 3520 records, of which 32 publications were suitable. A total of 84 fertility treatment cycles were analysed in 68 women. Median age at time of pregnancy was 32.5 years (IQR 30.0, 33.9 years). There were 60 clinical pregnancies resulting in 70 live births (including 16 multifetal births). Four women developed ovarian hyperstimulation syndrome which were associated with acute kidney injury. Hypertensive disorders complicated 26 pregnancies (38.3%), 24 (35.3%) pregnancies were preterm delivery, and low birth weight was present in 42.6% of pregnancies. Rates of live birth and miscarriage were similar for women with CKD requiring ART or having natural conception. However, more women with ART developed pre-eclampsia (p < 0.05) and had multifetal deliveries (p < 0.001), furthermore the babies were lower gestational ages (p < 0.001) and had lower birth weights (p < 0.001).

conclusionThis systematic review represents the most comprehensive assessment of fertility outcomes in patients with CKD following ART. However, the high reported live birth rate is likely related to reporting bias. Patient selection remains crucial in order to maximise patient safety, screen for adverse events and optimise fertility outcomes.

Indexed as

Acute Kidney InjuryRenal Insufficiency, ChronicFemaleHumansInfantInfant, NewbornKidneyLive BirthPregnancyReproductive Techniques, AssistedChronic kidney diseaseFertility treatmentFetal outcomesPregnancy

Identifiers

PMID36396849
PMCPMC9700651
OpenAlexW4309265004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.