Evidence map›Paper›PMID 36396757›Full record

ArticleCommunications biology2022

Phosphatidylinositol 4,5-bisphosphate (PIP

Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J F Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch and 11 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. PIPNature communications · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Oligomerization of Monoamine Transporters.Sub-cellular biochemistry · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 4 countries.

Dino LuethiInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.ORCID 0000-0003-0874-4875
Julian MaierInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.ORCID 0000-0001-6016-1947
Deborah RudinInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Dániel SzöllősiInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.ORCID 0000-0003-4641-3065
Thomas J F AngenoorthInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Stevan StankovicInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Matthias SchittmayerInstitute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.
Isabella BurgerInstitute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.ORCID 0000-0001-6419-1270
Jae-Won YangInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.ORCID 0000-0001-8928-0130
Kathrin JaentschInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Marion HolyInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Anand Kant DasInstitute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria.
Mario BrameshuberInstitute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria.
Gisela Andrea Camacho-HernandezMedicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD, 21224, USA.
Andrea CasiraghiMedicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD, 21224, USA.ORCID 0000-0002-6256-5694
Amy Hauck NewmanMedicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD, 21224, USA.ORCID 0000-0002-4812-9474
Oliver KudlacekInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Ruth Birner-GruenbergerInstitute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.
Thomas StocknerInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Gerhard J SchützInstitute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria. schuetz@iap.tuwien.ac.at.ORCID 0000-0003-1542-1089
Harald H SitteInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria. harald.sitte@meduniwien.ac.at.ORCID 0000-0002-1339-7444
Medical University of Vienna · ATTU Wien · ATNational Institute on Drug Abuse · USNew York University Abu Dhabi · AE

Funding

Monoamine Transporter NanoprobesZIADA000610 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 2016 to 2020
$2.5M
Austrian Science Fund FWF DOC 33Austrian Science Fund FWF P 33955Intramural NIH HHS ZIA DA000610
6 · The paper itself

Abstract

The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic activity by clearing extracellular norepinephrine in the synaptic cleft. Here, we investigate the subunit stoichiometry and function of NET using single-molecule fluorescence microscopy and flux assays. In particular, we show the effect of phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Norepinephrine Plasma Membrane Transport ProteinsPhosphatidylinositolsBiological TransportDimerizationInositol PhosphatesNorepinephrineInositol PhosphatesNorepinephrineNorepinephrine Plasma Membrane Transport ProteinsPhosphatidylinositols

Identifiers

PMID36396757
PMCPMC9672106
OpenAlexW4309509632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.