Evidence map›Paper›PMID 36396681›Full record

ArticleScientific reports2022

Predicting survival of glioblastoma from automatic whole-brain and tumor segmentation of MR images.

Sveinn Pálsson, Stefano Cerri, Hans Skovgaard Poulsen, Thomas Urup, Ian Law, Koen Van Leemput

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sveinn PálssonDepartment of Health Technology, Technical University of Denmark, Lyngby, Denmark. sveinnpals1@gmail.com.
Stefano CerriDepartment of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Hans Skovgaard PoulsenDepartment of Oncology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark.
Thomas UrupDepartment of Oncology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark.
Ian LawDepartment of Clinical Physiology, Nuclear Medicine and PET, Center of Diagnostic Investigation, Rigshospitalet, Copenhagen, Denmark.
Koen Van LeemputDepartment of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Rigshospitalet · DKTechnical University of Denmark · DKAthinoula A. Martinos Center for Biomedical Imaging · US

Funding

Computational Imaging Biomarkers of Multiple SclerosisR01NS112161 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VAN LEEMPUT, KOEN · 2019 to 2023
$1.5M
H2020 Marie Skłodowska-Curie Actions 765148NINDS NIH HHS R01 NS112161
6 · The paper itself

Abstract

Survival prediction models can potentially be used to guide treatment of glioblastoma patients. However, currently available MR imaging biomarkers holding prognostic information are often challenging to interpret, have difficulties generalizing across data acquisitions, or are only applicable to pre-operative MR data. In this paper we aim to address these issues by introducing novel imaging features that can be automatically computed from MR images and fed into machine learning models to predict patient survival. The features we propose have a direct anatomical-functional interpretation: They measure the deformation caused by the tumor on the surrounding brain structures, comparing the shape of various structures in the patient's brain to their expected shape in healthy individuals. To obtain the required segmentations, we use an automatic method that is contrast-adaptive and robust to missing modalities, making the features generalizable across scanners and imaging protocols. Since the features we propose do not depend on characteristics of the tumor region itself, they are also applicable to post-operative images, which have been much less studied in the context of survival prediction. Using experiments involving both pre- and post-operative data, we show that the proposed features carry prognostic value in terms of overall- and progression-free survival, over and above that of conventional non-imaging features.

Indexed as

Brain NeoplasmsGlioblastomaBrainHumansMagnetic Resonance ImagingPrognosis

Identifiers

PMID36396681
PMCPMC9671967
OpenAlexW3204589576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.