ArticleNature communications2022
Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Generation and characterization of humanized CD4 knock-in mice expressing chimeric mouse/human CD4 protein.Lab animal · 2026Article
- Mechanotransduction through T cell receptors: consensus, controversies and future outlooks.Experimental & molecular medicine · 2026Review
- Mechanoimmunology: past, present, and future perspectives.Mechanobiology in medicine · 2026Review
- ProTCR: a protein language model-driven framework for decoding TCR-antigen recognition toward precision immunotherapies.Briefings in bioinformatics · 2026Article
- Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds.Frontiers in immunology · 2026Article
- Mechanisms of T cell activation: Integrating signaling pathways, experimental models, and therapeutic implications.EXCLI journal · 2026Review
- Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds.bioRxiv : the preprint server for biology · 2025Article
- Synthetic mechanoreceptor engineering: From genetic encoding to DNA nanotechnology-based reprogramming.Mechanobiology in medicine · 2025Review
- Advances in ligand-based surface engineering strategies for fine-tuning T cell mechanotransduction toward efficient immunotherapy.Biophysical journal · 2025Review
- CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation.Cellular & molecular immunology · 2025Article
- pMHChat, characterizing the interactions between major histocompatibility complex class II molecules and peptides with large language models and deep hypergraph learning.Briefings in bioinformatics · 2025Article
- Identifying T cell antigen at the atomic level with graph convolutional network.Nature communications · 2025Article
- A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide.Nature communications · 2025Article
- TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity.Cell research · 2025Article
- The TCR and LCK: foundations for T-cell activation and therapeutic innovation.Frontiers in immunology · 2025Review
- Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer.Theranostics · 2025Review
- Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome.Science advances · 2024Article
- Mechanical force matters in early T cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- DNA origami: Interrogating the nano-landscape of immune receptor activation.Biophysical journal · 2024Review
- Mechanical forces amplify TCR mechanotransduction in T cell activation and function.Applied physics reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Muaz Nik Rushdi *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0001-6406-1521
Victor Pan *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Kaitao Li *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0003-0617-3546
Hyun-Kyu Choi *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Stefano TravaglinoWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Jinsung HongWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Fletcher GriffittsParker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
Pragati AgnihotriW. M. Keck Laboratory for Structural Biology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, USA.
Roy A MariuzzaW. M. Keck Laboratory for Structural Biology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, USA.ORCID 0000-0003-0748-5875
Yonggang KeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. yonggang.ke@emory.edu.ORCID 0000-0003-1673-2153
Cheng ZhuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. cheng.zhu@bme.gatech.edu.ORCID 0000-0002-1718-565X
Georgia Institute of Technology · USAdvanced Bioscience Laboratories (United States) · USEmory University · USInstitute for Bioscience and Biotechnology Research
Funding
Mechanisms of impaired T-cell mechanosensing of melanoma antigensU01CA214354 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI KROGSGAARD, MICHELLE, ZHU, CHENG · 2017 to 2021
$3.9MExploiting the Mechanobiology of PD-1 for Cancer ImmunotherapyU01CA250040 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2020 to 2024
$3.5MStructure and Activation of a Multiprotein Signaling ComplexR01AI129893 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI MARIUZZA, ROY A, ORBAN, JOHN · 2017 to 2021
$3.5MMechanisms of initiation of T-cell signaling by the TCR-CD3 complexR01GM124489 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE · 2018 to 2021
$2.1MDNA origami based molecular probes for quantitative study on TCR/CD8 binding with pMHCsR21AI135753 · NIAID · EMORY UNIVERSITY · PI KE, YONGGANG, ZHU, CHENG · 2018 to 2019
$428kNCI NIH HHS U01 CA214354NCI NIH HHS U01 CA250040NIAID NIH HHS R01 AI129893NIAID NIH HHS R21 AI135753NIGMS NIH HHS R01 GM124489U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA214354U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA250040U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI129893U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI135753U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM124489
Abstract
Antigen recognition by the T cell receptor (TCR) of CD4
Indexed as
AntigensReceptors, Antigen, T-CellHistocompatibility AntigensMajor Histocompatibility ComplexPeptidesAntigensHistocompatibility AntigensPeptidesReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.