ArticleNature communications2022
Patterned mechanical feedback establishes a global myosin gradient.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Ectoderm tensile stress controls mesoderm internalization during embryo gastrulation.Nature communications · 2026Article
- Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Article
- DynamicAtlas: a morphodynamic atlas for Drosophila development.Nature methods · 2026Article
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Searching for physical principles of morphogenesis.Development (Cambridge, England) · 2025Review
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- Blender tissue cartography: an intuitive tool for the analysis of dynamic 3D microscopy data.bioRxiv : the preprint server for biology · 2025Article
- Control of tissue flows and embryo geometry in avian gastrulation.Nature communications · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Rectification of planar orientation angle switches behavior and replenishes contractile junctions.The Journal of cell biology · 2025Article
- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster.Developmental cell · 2025Article
- Article
- Article
- Signatures of structural disorder in the developingPRX life · 2024Article
- A geometric-tension-dynamics model of epithelial convergent extension.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Proliferation symmetry breaking in growing tissues.bioRxiv : the preprint server for biology · 2024Article
- The developmental mechanics of divergent buckling patterns in the chick gut.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Confinement promotes nematic alignment of spindle-shaped cells during Drosophila embryogenesis.Development (Cambridge, England) · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Morphogenesis, the coordinated execution of developmental programs that shape embryos, raises many fundamental questions at the interface between physics and biology. In particular, how the dynamics of active cytoskeletal processes are coordinated across the surface of entire embryos to generate global cell flows is poorly understood. Two distinct regulatory principles have been identified: genetic programs and dynamic response to mechanical stimuli. Despite progress, disentangling these two contributions remains challenging. Here, we combine in toto light sheet microscopy with genetic and optogenetic perturbations of tissue mechanics to examine theoretically predicted dynamic recruitment of non-muscle myosin II to cell junctions during Drosophila embryogenesis. We find dynamic recruitment has a long-range impact on global myosin configuration, and the rate of junction deformation sets the rate of myosin recruitment. Mathematical modeling and high frequency analysis reveal myosin fluctuations on junctions around a mean value set by mechanical feedback. Our model accounts for the early establishment of the global myosin pattern at 80% fidelity. Taken together our results indicate spatially modulated mechanical feedback as a key regulatory input in the establishment of long-range gradients of cytoskeletal configurations and global tissue flow patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.