ArticleNeuroImage2022
Relationship of prefrontal brain lateralization to optimal cognitive function differs with age.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Harnessing Brain Age-Specific Effects on the Associations Between Sleep Quality, Glymphatic Function, and Cognition in Normal Ageing Adults: Insights for Gerotherapeutics.Neurology and therapy · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Association of Malaysian-MIND Diet Scores with Brain Activation in Older Adults: A Functional MRI Study.Biomedicines · 2026Article
- Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment.Scientific reports · 2025Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Age differences in BOLD modulation to task difficulty as a function of amyloid burden.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Brain gray matter morphometry relates to onset age of bilingualism and theory of mind in young and older adults.Scientific reports · 2024Article
- Differential spatial working memory-related functional network reconfiguration in young and older adults.Network neuroscience (Cambridge, Mass.) · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Lack of effects of online HD-tDCS over the left or right DLPFC in an associative memory and metamemory monitoring task.PloS one · 2024Article
- When Age Tips the Balance: a Dual Mechanism Affecting Hemispheric Specialization for Language.bioRxiv : the preprint server for biology · 2023Article
- Functional MRI Lateralization [M1] of dlPFC and Implications for Transcranial Magnetic Stimulation (TMS) Targeting.Diagnostics (Basel, Switzerland) · 2023Article
- Differential effects of ageing on the neural processing of speech and singing production.Frontiers in aging neuroscience · 2023Article
- The latent organization of white matter microstructure and its relation to fluid intelligence.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
There is considerable debate about whether additional fMRI-measured activity in the right prefrontal cortex readily observed in older adults represents compensatory activation that enhances cognition or whether maintenance of youthful brain activity best supports cognitive function in late adulthood. To investigate this issue, we tested a large lifespan sample of 461 adults (aged 20-89) and treated degree of left-lateralization in ventrolateral and dorsolateral prefrontal cortex during a semantic judgment fMRI task as an individual differences variable to predict cognition. We found that younger adults were highly left-lateralized, but lateralization did not predict better cognition, whereas higher left-lateralization of prefrontal cortex predicted better cognitive performance in middle-aged adults, providing evidence that left-lateralized, youth-like patterns are optimal in middle age. This relationship was reversed in older adults, with lower laterality scores associated with better cognition. The findings suggest that bilaterality in older adults facilitates cognition, but early manifestation of this pattern during middle age is characteristic of low performers. Implications of these findings for current theories of neurocognitive aging are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.