ArticleThe Journal of allergy and clinical immunology2023
Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods.
Article in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Social Determinants of Health in Pediatric Asthma and Allergic Diseases: A Systematic Review.Epidemiologia (Basel, Switzerland) · 2025Review
- The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025Review
- Indoor allergen exposure and its association to upper respiratory infections and pulmonary outcomes among children with asthma.The Journal of allergy and clinical immunology · 2024Article
- Indoor air pollution and airway health.The Journal of allergy and clinical immunology · 2024Review
- Impact of socioeconomic factors on allergic diseases.The Journal of allergy and clinical immunology · 2024Review
- Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months.Environmental research · 2023Article
- Indoor Environmental Exposures and Their Relationship to Allergic Diseases.The journal of allergy and clinical immunology. In practice · 2023Article
- General Anesthesia in Early Childhood Significantly Reduces Asthma Incidence and Clinical Visits: A Nationwide Population-Based Cohort Study.Children (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAir trapping is an obstructive phenotype that has been associated with more severe and unstable asthma in children. Air trapping has been defined using pre- and postbronchodilator spirometry. The causes of air trapping are not completely understood. It is possible that environmental exposures could be implicated in air trapping in children with asthma.
objectiveWe investigated the association between indoor exposures and air trapping in urban children with asthma.
methodsChildren with asthma aged 5 to 17 years living in Baltimore and enrolled onto the Environmental Control as Add-on Therapy for Childhood Asthma study were evaluated for air trapping using spirometry. Aeroallergen sensitization was assessed at baseline, and spirometry was performed at 0, 3, and 6 months. Air trapping was defined as an FVC z score of less than -1.64 or a change in FVC with bronchodilation of ≥10% predicted. Logistic normal random effects models were used to evaluate associations of air trapping and indoor exposures.
resultsAirborne and bedroom floor mouse allergen concentrations were associated with air trapping but not airflow limitation (odds ratio 1.19, 95% confidence interval 1.02-1.37, P = .02 per 2-fold increase in airborne mouse allergen; odds ratio 1.23, 95% confidence interval 1.07-1.41, P = .003 per 2-fold increase in bedroom floor mouse allergen). Other indoor exposures (cockroach, cat, dog, dust mite, particulate matter, and nicotine) were not associated with air trapping or airflow limitation.
conclusionMouse allergen exposure, but not other indoor exposure, was associated with air trapping in urban children with asthma.
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Registered trials
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