Evidence map›Paper›PMID 36395385›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Formation of the glomerular microvasculature is regulated by VEGFR-3.

Michael D Donnan, Dilip K Deb, Tuncer Onay, Rizaldy P Scott, Eric Ni, Yalu Zhou, Susan E Quaggin

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael D DonnanNorthwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois.ORCID 0000-0002-9470-648X
Dilip K DebNorthwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois.
Tuncer OnayNorthwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois.ORCID 0000-0001-8891-2300
Rizaldy P ScottNorthwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois.ORCID 0000-0002-0288-8862
Eric NiLake Erie College of Osteopathic Medicine, Greensburg, Pennsylvania.ORCID 0000-0003-2209-5787
Yalu ZhouNorthwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois.
Susan E QuagginNorthwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois.ORCID 0000-0002-3706-5727
Northwestern University · USLake Erie College of Osteopathic Medicine · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Pathogenesis of Diabetic NephropathyR01DK060635 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QUAGGIN, SUSAN E. · 2002 to 2023
$6.6M
Activation of the Angiopoietin-Tie2/TEK Pathway to Treat Ocular Hypertension and GlaucomaR01EY025799 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JIN, JING, QUAGGIN, SUSAN E. · 2016 to 2024
$5.8M
Therapeutics Development Core (Core B)P30DK114857 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QUAGGIN, SUSAN E. · 2018 to 2022
$5.7M
Resource Development CoreU54DK137516 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Evan Alexander Scott · 2023 to 2026
$4.8M
Exploiting Tie2 Activation for the Treatment of Vascular DiseasesR01HL124120 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QUAGGIN, SUSAN E. · 2014 to 2017
$1.5M
The 10x Chromium System for High-Throughput Single Cell GenomicsS10OD025120 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, XINKUN · 2019 to 2019
$79k
NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL124120NIDDK NIH HHS P30 DK114857NIDDK NIH HHS R01 DK060635NIDDK NIH HHS U54 DK137516NIH HHS S10 OD025120
6 · The paper itself

Abstract

Microvascular dysfunction is a key driver of kidney disease. Pathophysiological changes in the kidney vasculature are regulated by vascular endothelial growth factor receptors (VEGFRs), supporting them as potential therapeutic targets. The tyrosine kinase receptor VEGFR-3, encoded by

Indexed as

Kidney DiseasesVascular Endothelial Growth Factor Receptor-3AnimalsCapillariesEndothelial CellsMiceVascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor Receptor-3developmentglomeruluskidneyvascular endothelial growth factor receptor 3vasculature

Identifiers

PMID36395385
PMCPMC9836230
OpenAlexW4309231273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.