ArticleScience (New York, N.Y.)2022
Cross-trait assortative mating is widespread and inflates genetic correlation estimates.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 3 of them syntheses that pooled it.
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123citing papers in PubMed, 3 pooled it
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Who cites it
123 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.Nature human behaviour · 2024Pooled it
- The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.Nature human behaviour · 2024Pooled it
- Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits.Nature human behaviour · 2023Pooled it
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Convex approaches to isolate the shared and distinct genetic components of complex traits.Bioinformatics (Oxford, England) · 2026Article
- Population-Level Implications of Parental Similarity for the Prevalence and Heritability of Psychiatric Disorders.JAMA psychiatry · 2026Article
- Genetic architectures of brain-related traits are shaped by strong selective constraints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- "Yet the Problem Remains": Why Genetic Determinism Still Haunts Biomedical Research.Bioethics · 2026Article
- Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.Research square · 2026Article
- Separating direct, indirect, and parent-of-origin genetic effects in the human population.Cell genomics · 2026Article
- Genetic pathways linking oxytocin-vasotocin hypothalamic subunit architecture with psychiatric and metabolic traits.Molecular psychiatry · 2026Article
- Improved heritability partitioning and enrichment analyses using summary statistics with graphREML.Nature genetics · 2026Article
- Multivariate maternal effects across the internalizing-externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Moderating effects of educational inequality on education polygenic scores, attained education and dementia-risk relationships.SSM - population health · 2026Article
- Genomic-Relatedness Matching Expands Population Coverage, Improves Power, and Reduces Bias in Genetic Association Analyses.medRxiv : the preprint server for health sciences · 2026Article
- Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.JCPP advances · 2026Article
- Challenges and future directions for Mendelian randomization.Nature genetics · 2026Review
- Why psychopathology research should avoid studying one mental disorder at a time: An intergenerational and developmental evidence base for understanding "p".Journal of psychopathology and clinical science · 2026Review
- What does psychopathology research have to gain by studying all mental disorders at the same time?Journal of psychopathology and clinical science · 2026Article
- A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating.Genetics · 2026Article
63 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Richard BorderDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-6293-2968
Georgios AthanasiadisInstitute of Biological Psychiatry, Mental Health Center Sct Hans, Copenhagen University Hospital-Mental Health Services CPH, 2100 Copenhagen, Denmark.ORCID 0000-0002-2927-4035
Alfonso BuilInstitute of Biological Psychiatry, Mental Health Center Sct Hans, Copenhagen University Hospital-Mental Health Services CPH, 2100 Copenhagen, Denmark.ORCID 0000-0002-1863-164X
Andrew J SchorkInstitute of Biological Psychiatry, Mental Health Center Sct Hans, Copenhagen University Hospital-Mental Health Services CPH, 2100 Copenhagen, Denmark.ORCID 0000-0003-4164-9335
Na CaiHelmholtz Pioneer Campus, Helmholtz Zentrum München, 85764 Neuherberg, Germany.ORCID 0000-0001-7496-2075
Alexander I YoungAnderson School of Management, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-9930-989X
Thomas WergeInstitute of Biological Psychiatry, Mental Health Center Sct Hans, Copenhagen University Hospital-Mental Health Services CPH, 2100 Copenhagen, Denmark.ORCID 0000-0003-1829-0766
Jonathan FlintCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-9427-4429
Kenneth S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0001-8689-6570
Sriram SankararamanDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1586-9641
Andy W DahlSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-6520-4766
Noah A ZaitlenDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-3553-3670
Funding
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MIdentifying the genetic causes of depression in a deeply phenotyped population from South KoreaU01MH126798 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHN, YONG MIN, FLINT, JONATHAN · 2021 to 2025
$8.9MMethods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3MTraining Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8MOptimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2MSINGLE-CELL MULTI-OMIC APPROACHES TO MECHANISTICALLY CHARACTERIZE PSYCHIATRIC DISORDER RISK LOCI IN THE HUMAN BRAINR01MH125252 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUO, CHONGYUAN · 2021 to 2025
$3.7MImproved methods for inference of genotype-specific response to environmental toxinsR01ES029929 · NIEHS · PRINCETON UNIVERSITY · PI AYROLES, JULIEN, CLARK, ANDREW G · 2019 to 2023
$3.6M(PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactionsR01CA227237 · NCI · DANA-FARBER CANCER INST · PI GUSEV, ALEXANDER, ZAITLEN, NOAH A · 2018 to 2022
$3.5M(8) Genetics of Immune Related Adverse Events and Response to ImmunotherapyR01CA227466 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2018 to 2023
$3.3MGenomic Approaches to Population Health in Multi-Ethnic Hospital SystemsR01HG011345 · NHGRI · UNIVERSITY OF COLORADO DENVER · PI ARBOLEDA, VALERIE A, GIGNOUX, CHRISTOPHER R · 2020 to 2023
$3.1MEpigenomics of asthma risk factors and clinical subtypes in minority childrenR01HL155024 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORRELL, LUISA N, ZAITLEN, NOAH A · 2021 to 2024
$2.9MGenome-Wide Analyses of Health and Well-Being PhenotypesR01AG042568 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2015 to 2021
$2.8MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS R01 CA227237NCI NIH HHS R01 CA227466NHGRI NIH HHS R01 HG006399NHGRI NIH HHS R01 HG011345NHGRI NIH HHS U01 HG009080NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL155024NIA NIH HHS R01 AG042568NIA NIH HHS R24 AG065184NIEHS NIH HHS R01 ES029929NIGMS NIH HHS R01 GM142112NIGMS NIH HHS R35 GM125055NIGMS NIH HHS R35 GM133531NIMH NIH HHS R01 MH122688NIMH NIH HHS R01 MH125252NIMH NIH HHS R01 MH130581NIMH NIH HHS U01 MH126798NINDS NIH HHS T32 NS048004Wellcome Trust
Abstract
The observation of genetic correlations between disparate human traits has been interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative mating (xAM) as an alternative explanation. We observe that xAM affects many phenotypes and that phenotypic cross-mate correlation estimates are strongly associated with genetic correlation estimates (
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Genome-Wide Association StudyMultifactorial InheritanceCell CommunicationHumansPhenotype
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