Observational studyThe British journal of surgery2023
Postoperative muscle loss, protein intake, physical activity and outcome associations.
Observational study in The British journal of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Preoperative low-energy diets for patients with a body mass index >30 kg/m2 undergoing non-bariatric surgery: pilot feasibility randomized clinical trial and a systematic review and meta-analysis of efficacy data.The British journal of surgery · 2026Pooled it
- The Role of Vitamin D Supplementation in Enhancing Muscle Strength Post-Surgery: A Systemic Review.Nutrients · 2025Pooled it
- Preoperative Weight Loss: Helpful, Harmful or Irrelevant?Obesity surgery · 2026Article
- Article
- Changes in Functional Capacity and Body Composition After a Multimodal Prehabilitation Program in Patients with Cancer undergoing Abdominal Surgery.Annals of surgical oncology · 2026Article
- Article
- Prehabilitative parenteral nutrition and surgery-related muscle loss in patients undergoing major upper gastrointestinal surgery: a single-centre observational cohort study.Frontiers in nutrition · 2026Article
- Sarcopenia in Colorectal Cancer Surgery-Minimally Invasive vs. Open.Journal of cachexia, sarcopenia and muscle · 2025Article
- Sedentary Duration and Systemic Health Burden: Nonlinear Associations with Muscle, Fat, and Vascular Phenotypes in a US Population-Based Study.Healthcare (Basel, Switzerland) · 2025Article
- Exploring the Potential Impact of Creatine Supplementation on Anesthetic Outcomes: A Comprehensive Review.Cureus · 2025Review
- Individual multimodal prehabilitation in high-risk patients undergoing major abdominal surgery following neoadjuvant treatment - a feasibility study.Langenbeck's archives of surgery · 2025Article
- Skeletal Muscle Index Changes on Locoregional Treatment Application After FOLFIRINOX and Survival in Pancreatic Cancer.Journal of cachexia, sarcopenia and muscle · 2025Article
- Consensus-based recommendations for optimizing perioperative nutritional support and muscle health in major surgery in India.Frontiers in nutrition · 2025Article
- Factors Influencing Rehabilitation Exercise Behavior in Elderly Rotator Cuff Repair Patients: A Qualitative Study Based on the Theory of Behavior Change Wheel.Patient preference and adherence · 2025Article
- The effects of beta-hydroxy-beta-methyl butyrate supplementation in surgical patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2025Article
- Association of Perioperative Skeletal Muscle Index Change With Outcome in Colorectal Cancer Patients.Journal of cachexia, sarcopenia and muscle · 2024Article
- Effect of preoperative physical activity on postoperative outcomes in esophageal cancer.Journal of physical therapy science · 2024Article
- Nutritional support in pancreatic cancer patients and its effect on nutritional status: an observational regional HPB network study investigating current practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Perioperative Management in Neuromuscular Diseases: A Narrative Review.Journal of clinical medicine · 2024Review
- Potential Food Inclination of Crab-Eating Macaques in Laboratory Environments: Enhancing Positive Reinforcement Training and Health Optimization.Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSkeletal muscle loss is often observed in intensive care patients. However, little is known about postoperative muscle loss, its associated risk factors, and its long-term consequences. The aim of this prospective observational study is to identify the incidence of and risk factors for surgery-related muscle loss (SRML) after major abdominal surgery, and to study the impact of SRML on fatigue and survival.
methodsPatients undergoing major abdominal cancer surgery were included in the MUSCLE POWER STUDY. Muscle thickness was measured by ultrasound in three muscles bilaterally (biceps brachii, rectus femoris, and vastus intermedius). SRML was defined as a decline of 10 per cent or more in diameter in at least one arm and leg muscle within 1 week postoperatively. Postoperative physical activity and nutritional intake were assessed using motility devices and nutritional diaries. Fatigue was measured with questionnaires and 1-year survival was assessed with Cox regression analysis.
resultsA total of 173 patients (55 per cent male; mean (s.d.) age 64.3 (11.9) years) were included, 68 of whom patients (39 per cent) showed SRML. Preoperative weight loss and postoperative nutritional intake were statistically significantly associated with SRML in multivariable logistic regression analysis (P < 0.050). The combination of insufficient postoperative physical activity and nutritional intake had an odds ratio of 4.00 (95 per cent c.i. 1.03 to 15.47) of developing SRML (P = 0.045). No association with fatigue was observed. SRML was associated with decreased 1-year survival (hazard ratio 4.54, 95 per cent c.i. 1.42 to 14.58; P = 0.011).
conclusionSRML occurred in 39 per cent of patients after major abdominal cancer surgery, and was associated with a decreased 1-year survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.