ArticleAnnals of intensive care2022
Association between frailty, delirium, and mortality in older critically ill patients: a binational registry study.
Article in Annals of intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- [Frailty in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Pooled it
- Preoperative Transcranial Doppler Findings and Postoperative Delirium After Cardiac Surgery in Elderly Patients: A Prospective Observational Study.Life (Basel, Switzerland) · 2026Article
- Associations of postoperative delirium with perioperative frailty worsening and their combined effect on 1-year mortality in older surgical patients: a prospective cohort study.European geriatric medicine · 2026Article
- [Special ethical aspects in older intensive care patients].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Association of Frailty and Delirium with Hospitalization Outcomes Among Older Adults With Rheumatic Diseases.ACR open rheumatology · 2026Article
- Frequent in dementia, deadliest without it: delirium and mortality in hospitalised older adults.Age and ageing · 2026Article
- Association of the Albumin-Bilirubin score with 7-day incident delirium risk following bloodstream infection in critically ill adults: evidence from a propensity-weighted cohort.BMC infectious diseases · 2026Article
- Validation of the confusion assessment method for intensive care.Open medicine (Warsaw, Poland) · 2026Article
- Impact of frailty on in-hospital outcomes in nonagenarian ICU patients: a binational multicenter analysis of 8,220 cases.Critical care (London, England) · 2025Article
- Review
- Clinical Characteristics Associated With Hospital Mortality and Length of Stay Among Older Adults Admitted With Delirium: Retrospective Analysis.HCA healthcare journal of medicine · 2025Article
- Age-specific vulnerability and high prevalence of delirium in pediatric intensive care based on a prospective cohort study.Scientific reports · 2024Article
- A comprehensive analysis of in-hospital adverse events after scopolamine administration: insights from a retrospective cohort study using a large nationwide inpatient database.BMC anesthesiology · 2024Article
- Article
- Delirium risk and mortality in people with pre-existing severe mental illness: a retrospective cohort study using linked datasets in England.Psychological medicine · 2024Article
- Incidence of Delirium in ICU Patients With and Without COVID-19 in a Costa Rican Hospital.Cureus · 2024Article
- Frailty in an Adult Acute Hospital Population: Predictors, Prevalence, and Outcomes.International journal of environmental research and public health · 2024Article
- Application of laboratory frailty index in predicting delirium in elderly patients with community-acquired pneumonia.Frontiers in aging · 2024Article
- Long-term mortality of critically ill patients with cancer and delirium who survived to discharge: a retrospective cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
- Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty and delirium are prevalent among older adults admitted to the intensive care unit (ICU) and associated with adverse outcomes; however, their relationships have not been extensively explored. This study examined the association between frailty and mortality and length of hospital stay (LOS) in ICU patients, and whether the associations are mediated or modified by an episode of delirium.
methodsRetrospective analysis of data from the Australian New Zealand Intensive Care Society Adult Patient Database. A total of 149,320 patients aged 65 years or older admitted to 203 participating ICUs between 1 January 2017 and 31 December 2020 who had data for frailty and delirium were included in the analysis.
resultsA total of 41,719 (27.9%) older ICU patients were frail on admission, and 9,179 patients (6.1%) developed delirium during ICU admission. Frail patients had significantly higher odds of in-hospital mortality (OR: 2.15, 95% CI 2.05-2.25), episodes of delirium (OR: 1.86, 95% CI 1.77-1.95), and longer LOS (log-transformed mean difference (MD): 0.24, 95% CI 0.23-0.25). Acute delirium was associated with 32% increased odds of in-hospital mortality (OR: 1.32, 95% CI 1.23-1.43) and longer LOS (MD: 0.54, 95% CI 0.50-0.54). The odds ratios (95% CI) for in-hospital mortality were 1.37 (1.23-1.52), 2.14 (2.04-2.24) and 2.77 (2.51-3.05) for non-frail who developed delirium, frail without delirium, and frail and developed delirium during ICU admission, respectively. There was very small but statistically significant effect of frailty on in-hospital mortality (b for indirect effect: 0.00037, P < 0.001) and LOS (b for indirect effect: 0.019, P < 0.001) mediated through delirium.
conclusionBoth frailty and delirium independently increase the risk of in-hospital mortality and LOS. Acute delirium is more common in frail patients; however, it does not mediate or modify a clinically meaningful amount of the association between frailty and in-hospital mortality and LOS.
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